DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycH and CCNH

DIOPT Version :9

Sequence 1:	NP_524207.1	Gene:	CycH / 40429	FlyBaseID:	FBgn0022936	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	XP_005248684.1	Gene:	CCNH / 902	HGNCID:	1594	Length:	329	Species:	Homo sapiens

Alignment Length:	309	Identity:	141/309 - (45%)
Similarity:	199/309 - (64%)	Gaps:	18/309 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPVSSQKRSWTFANEGQLMEFRVEQNSKYIESHEEEAQGRDL--NEHFLTSAEERLLLKQYEIY 63
            ||..|||||.|||::|.||...|.:.|.|:  ..:..|.|:.|  :..||...||..|.|.||..
Human     1 MYHNSSQKRHWTFSSEEQLARLRADANRKF--RCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKR 63

  Fly    64 LFDFCRRFEPTMPKCVVGTAFHYFKRFYLNNSPMDYHPKEILATCVFVACKVEEFNVSINQFVNN 128
            |.:||..|:|.||:.|||||..||||||||||.|:|||:.|:.||.|:||||:|||||..|||.|
Human    64 LLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGN 128

  Fly   129 IKGD---RNKATDIVLSNELLLIGQLNYYLTIHNPFRPIEGFLIDIKTR-SNMQNPDRLRPHIDS 189
            ::..   :.||.:.:|..|||||.|||::|.:|||:||.||||||:||| ..::||:.||...|.
Human   129 LRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADD 193

  Fly   190 FIDSTYYSDACLLHTPSQIALAAVLHAASREQENLDSYVTD-LLFVSAREKLPGLIDAVRKIRIM 253
            |::....:||.||:|||||||.|:|.:|||....::||::: |:....|..|..|:|.::.:|.:
Human   194 FLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNL 258

  Fly   254 VKQYQQPDREKVKAIEKKLDKCRNQANNPDSELYKE---RLRRLYTDED 299
            ||:|:.|..|:|..:::||::|.:      :||...   :.|:.|.|:|
Human   259 VKKYEPPRSEEVAVLKQKLERCHS------AELALNVITKKRKGYEDDD 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycH	NP_524207.1	ccl1	2..307	CDD:129660	140/308 (45%)
		CYCLIN	63..>127	CDD:238003	41/63 (65%)
		Cyclin_C_2	159..257	CDD:293504	45/99 (45%)
CCNH	XP_005248684.1	ccl1	2..308	CDD:129660	140/308 (45%)
		CYCLIN	62..152	CDD:214641	50/89 (56%)
		Cyclin_C_2	162..262	CDD:293504	45/99 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149873
Domainoid	1	1.000	111	1.000	Domainoid score	I6278
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H946
Inparanoid	1	1.050	247	1.000	Inparanoid score	I3275
Isobase	1	0.950	-	0	Normalized mean entropy	S2435
OMA	1	1.010	-	-		QHG56153
OrthoDB	1	1.010	-	-		D1469819at2759
OrthoFinder	1	1.000	-	-		FOG0005252
OrthoInspector	1	1.000	-	-		oto89937
orthoMCL	1	0.900	-	-		OOG6_102792
Panther	1	1.100	-	-	LDO	PTHR10026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R195
SonicParanoid	1	1.000	-	-		X3774
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750