DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycH and CCNL1

DIOPT Version :9

Sequence 1:	NP_524207.1	Gene:	CycH / 40429	FlyBaseID:	FBgn0022936	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_064703.1	Gene:	CCNL1 / 57018	HGNCID:	20569	Length:	526	Species:	Homo sapiens

Alignment Length:	243	Identity:	56/243 - (23%)
Similarity:	104/243 - (42%)	Gaps:	52/243 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 MPKCVVGTAFHYFKRFYLNNSPMDYHPKEILA-TCVFVACKVEEFNVSINQFVN------NIKGD 132
            :|:..:.|....|.||:.:.|.:. |..||:| .|:.:|.|:||....|...:|      .::|.
Human    99 LPQVAMATGQVLFHRFFYSKSFVK-HSFEIVAMACINLASKIEEAPRRIRDVINVFHHLRQLRGK 162

  Fly   133 RNKATDI-----------VLSNELLLIGQLNYYLTIHNPFRPIEGFL---------IDIKTRSNM 177
            |..:..|           |:..|..::.:|.:.:.:.:|.:.|..:|         ..::|..|.
Human   163 RTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQTLVQTAWNY 227

  Fly   178 QNPDRLRPHIDSFIDSTYYSDACLLHTPSQIALAAVLHAASREQENLDSYV-TDLLFVSAREKLP 241
            .| |.||.::  |:          ...|..||.|.:..||...|..|.:.. ..|||.:..|::.
Human   228 MN-DSLRTNV--FV----------RFQPETIACACIYLAARALQIPLPTRPHWFLLFGTTEEEIQ 279

  Fly   242 GLIDAVRKIRIMVKQYQQPDREKV-KAIEKK---LDKCRNQAN--NPD 283
            .:  .:..:|:..:  ::|:.|.: |.:||:   |.:.:.:|.  |||
Human   280 EI--CIETLRLYTR--KKPNYELLEKEVEKRKVALQEAKLKAKGLNPD 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycH	NP_524207.1	ccl1	2..307	CDD:129660	56/243 (23%)
		CYCLIN	63..>127	CDD:238003	16/52 (31%)
		Cyclin_C_2	159..257	CDD:293504	23/107 (21%)
CCNL1	NP_064703.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		CYCLIN_SF	40..195	CDD:424085	23/96 (24%)
		Cyclin-like 1	88..190		22/91 (24%)
		CYCLIN_SF	199..321	CDD:424085	30/138 (22%)
		Cyclin-like 2	203..287		21/98 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..526		3/6 (50%)
		RS	390..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149872
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740