DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycH and ccnh

DIOPT Version :9

Sequence 1:	NP_524207.1	Gene:	CycH / 40429	FlyBaseID:	FBgn0022936	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	XP_021331815.1	Gene:	ccnh / 541325	ZFINID:	ZDB-GENE-050320-13	Length:	331	Species:	Danio rerio

Alignment Length:	323	Identity:	134/323 - (41%)
Similarity:	199/323 - (61%)	Gaps:	25/323 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYPVSSQKRSWTFANEGQLMEFRVEQNSKYIESHEEEAQGR-DLNEH-FLTSAEERLLLKQYEIY 63
            ||..||||:.||:..|..|.:.|:|.|.|:..  :..:.|: .:||. .|...||::|.|.||..
Zfish    13 MYHNSSQKKFWTYDKEETLDKLRLEANQKFCS--KALSSGKPGINESTLLNEQEEKVLFKHYEKR 75

  Fly    64 LFDFCRRFEPTMPKCVVGTAFHYFKRFYLNNSPMDYHPKEILATCVFVACKVEEFNVSINQFVNN 128
            |.|||..|:|.|||.|||||..||:|||||||.|:|||:.|:.||.:::|||:|||||..|||.|
Zfish    76 LLDFCAVFKPVMPKSVVGTACMYFRRFYLNNSLMEYHPRTIMLTCAYLSCKVDEFNVSSTQFVGN 140

  Fly   129 IK---GDRNKATDIVLSNELLLIGQLNYYLTIHNPFRPIEGFLIDIKTR-SNMQNPDRLRPHIDS 189
            ::   ..:.:|.|.:|..|||||.|||::|.:|||:||:||||||:||| ..::||:.||...:.
Zfish   141 LQESPAGQERAVDQILEYELLLIQQLNFHLVVHNPYRPLEGFLIDLKTRYPLLENPEMLRKSAED 205

  Fly   190 FIDSTYYSDACLLHTPSQIALAAVLHAASREQENLDSYVTDLLFVSA-REKLPGLIDAVRKIRIM 253
            |::....:||.||.:||||||.|||::|:|....:|.|:.:.:.:.. :|.|..:.:::|::..:
Zfish   206 FLNRATMTDAGLLFSPSQIALTAVLNSAARAGLKMDVYLNECMGLKEDKETLSKMYESMRRMTSL 270

  Fly   254 VKQYQQPDREKVKAIEKKLDKC---------RNQANNPDSELYKERLRRLYTDE----DDMPA 303
            ||.|:.|..|:|...::||::.         |......|..:.|   |::..||    ||:.|
Zfish   271 VKAYELPKAEEVSICKQKLERIYAEFATNLKRKHGYEDDDHVVK---RQMVADEEWTDDDLDA 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycH	NP_524207.1	ccl1	2..307	CDD:129660	133/322 (41%)
		CYCLIN	63..>127	CDD:238003	40/63 (63%)
		Cyclin_C_2	159..257	CDD:293504	40/99 (40%)
ccnh	XP_021331815.1	CCL1	14..314	CDD:333358	126/301 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584015
Domainoid	1	1.000	99	1.000	Domainoid score	I7088
eggNOG	1	0.900	-	-		E1_COG5333
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H946
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3364
OMA	1	1.010	-	-		QHG56153
OrthoDB	1	1.010	-	-		D1469819at2759
OrthoFinder	1	1.000	-	-		FOG0005252
OrthoInspector	1	1.000	-	-		oto41151
orthoMCL	1	0.900	-	-		OOG6_102792
Panther	1	1.100	-	-	LDO	PTHR10026
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R195
SonicParanoid	1	1.000	-	-		X3774
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840