DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YY2 and yy1

DIOPT Version :9

Sequence 1:	NP_996806.2	Gene:	YY2 / 404281	HGNCID:	31684	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_001116880.1	Gene:	yy1 / 100126440	XenbaseID:	XB-GENE-961263	Length:	372	Species:	Xenopus tropicalis

Alignment Length:	387	Identity:	219/387 - (56%)
Similarity:	277/387 - (71%)	Gaps:	32/387 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MASNEDFSITQD-LEIPADIVELHDINVEPLPMEDIPTESVQYEDVDGNWIYGGHNHPPLMVLQP 64
            |||.:...|..| .|:||:|||||:|.||.:|:|.|.|..|..::.|.:.....|:|.|::.|||
Frog     1 MASGDTLYIASDGSEMPAEIVELHEIEVESIPVETIETTVVGDDEDDDDDPVHHHHHQPMIALQP 65

Human    65 LFTNTGYGDHDQEMLMLQTQEEVVGYCDSDNQLGNDLEDQLALP---DSIEDEHFQMTLASLSAS 126
            |.::.....|.||::::||:|||||..|||.:..:..|||:.:|   .:.|||:.:.||.:::..
Frog    66 LDSDDAVHPHHQEVILVQTREEVVGGDDSDLRADDGFEDQILIPVPAPAGEDEYIEQTLVTVAGK 130

Human   127 AASTSTSTQSRSKK---PSKKPSGKSATSTEANPAGSSSSLGTRKWEQKQMQVKTLEGEFSVTMW 188
                  |:..|.||   .|.|.|.|.:..:.|.|:|       |||||||:|:||||||||||||
Frog   131 ------SSGGRMKKGGGGSGKKSSKKSYLSGAEPSG-------RKWEQKQVQIKTLEGEFSVTMW 182

Human   189 SPNDNND--------QGAVGEGQAENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTKVKPKR 245
            :.:|..|        :..:||   .:|||||||:.||||||||:||||||||||||||.::||::
Frog   183 ASDDKKDIDHETVVEEQIIGE---NSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRK 244

Human   246 SK-GEPPKTVPCSYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRRHQLVHTGEK 309
            .| .:.|:|:.|.:.||.|||||.:|||||||.|||||||||||||||:|||||:||||||||||
Frog   245 IKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEK 309

Human   310 PFQCTFEGCGKRFSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNN 371
            ||||||||||||||||||||||:||||||:|:|||||.||:|||||||||:|||||.|.|||
Frog   310 PFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNN 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YY2	NP_996806.2	Mediates transcriptional activation	32..102		25/69 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..172		15/48 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..210		9/31 (29%)
		Mediates transcriptional repression	237..372		106/136 (78%)
		zf-C2H2_8	255..334	CDD:292531	67/78 (86%)
		C2H2 Zn finger	256..278	CDD:275368	15/21 (71%)
		C2H2 Zn finger	285..305	CDD:275368	17/19 (89%)
		zf-H2C2_2	298..323	CDD:290200	23/24 (96%)
		COG5048	<309..>372	CDD:227381	55/63 (87%)
		C2H2 Zn finger	313..335	CDD:275368	20/21 (95%)
		zf-H2C2_2	327..354	CDD:290200	21/26 (81%)
		C2H2 Zn finger	343..365	CDD:275368	18/21 (86%)
yy1	NP_001116880.1	COG5048	<226..365	CDD:227381	110/138 (80%)
		C2H2 Zn finger	256..278	CDD:275368	15/21 (71%)
		C2H2 Zn finger	285..305	CDD:275368	17/19 (89%)
		C2H2 Zn finger	313..335	CDD:275368	20/21 (95%)
		C2H2 Zn finger	343..365	CDD:275368	18/21 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D244996at32523
OrthoFinder	1	1.000	-	-		FOG0003443
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3337
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020