Protein Alignment YY2 and Yy2

DIOPT Version :10

• Sequence 1: NP_996806.2
• Gene: YY2 / 404281
• HGNCID: 31684
• Length: 372
• Species: Homo sapiens
• Sequence 2: NP_001092193.1
• Gene: Yy2 / 100073351
• MGIID: 3837947
• Length: 378
• Species: Mus musculus
• Alignment Length: 375
• Identity: 209/375 - (55%)
• Similarity: 267/375 - (71%)
• Gaps: 23/375 - (6%)

Human    10 TQDLEIPADIVEL---HDI-NVEPLPMEDIPTESVQ-YEDVDGNWIYGGHNHPPLMVLQPLF-TN 68
            |:..|||||.|||   .:| ::|.:.:|....:::: |.||..:|.:|...|.|::.||||. ::
Mouse    13 TESAEIPADFVELLPPDNIGDIEAVSLETSVGQTIEVYGDVGVDWAHGSQYHSPVIALQPLVGSS 77

Human    69 TGYGDHDQEMLMLQT-QEEVVGYCDSDNQL-GNDLEDQLALPDSIEDEHFQMTLASLSASAASTS 131
            ....|||:||.::|| :||||||.||||.| ..:...|:.||.: ||::.|.|.||.:...|:.:
Mouse    78 LSSRDHDKEMFVVQTREEEVVGYQDSDNLLFSPEFGSQMVLPVN-EDDYLQPTTASFTGFLAAEN 141

Human   132 TSTQSRSKKPSKKPSGKSATSTEANPAGSSSS----LGTRKWEQKQMQVKTLEGEFSVTMWSPND 192
            ...:....:      |.....|....||:..|    ||.::||||  |:..|:|||..|||. :.
Mouse   142 GQGELSPYE------GNLCGLTTFIEAGAEESVNADLGDKQWEQK--QIDGLDGEFPFTMWD-DV 197

Human   193 NNDQGAVGEGQA-ENPPDYSEYLKGKKLPPGGLPGIDLSDPKQLAEFTKVKPKRSKGEPPKTVPC 256
            |..:..:.|.|| |:|||||||:.|||.||.|:|||||||||||||||.::||:.||:.|:.:.|
Mouse   198 NEKEDPIAEEQAGESPPDYSEYMTGKKFPPEGIPGIDLSDPKQLAEFTSMRPKKPKGDFPRPIAC 262

Human   257 SYSGCEKMFRDYAAMRKHLHIHGPRVHVCAECGKAFLESSKLRRHQLVHTGEKPFQCTFEGCGKR 321
            |:.||||||:|.:|||||||||||||||||||||||:|||||:|||||||||||:||||||||:|
Mouse   263 SHKGCEKMFKDNSAMRKHLHIHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPYQCTFEGCGRR 327

Human   322 FSLDFNLRTHLRIHTGDKPFVCPFDVCNRKFAQSTNLKTHILTHVKTKNN 371
            ||||||||||:||||||||||||||.||:|||||||||:|||||||.||:
Mouse   328 FSLDFNLRTHVRIHTGDKPFVCPFDACNKKFAQSTNLKSHILTHVKNKND 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YY2	NP_996806.2	Mediates transcriptional activation	32..102		30/73 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	126..172		10/49 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..210		10/24 (42%)
		Mediates transcriptional repression	237..372		109/135 (81%)
		C2H2 Zn finger	256..278	CDD:275368	16/21 (76%)
		COG5048	<283..>357	CDD:227381	66/73 (90%)
		C2H2 Zn finger	285..305	CDD:275368	17/19 (89%)
		C2H2 Zn finger	313..335	CDD:275368	19/21 (90%)
		C2H2 Zn finger	343..365	CDD:275368	18/21 (86%)
Yy2	NP_001092193.1	Mediates transcriptional activation. /evidence=ECO:0000250	39..113		30/73 (41%)
		Mediates transcriptional repression. /evidence=ECO:0000250	243..378		109/135 (81%)
		C2H2 Zn finger	265..284	CDD:275368	14/18 (78%)
		COG5048	<289..378	CDD:227381	79/89 (89%)
		C2H2 Zn finger	291..311	CDD:275368	17/19 (89%)
		C2H2 Zn finger	319..341	CDD:275368	19/21 (90%)
		C2H2 Zn finger	349..371	CDD:275368	18/21 (86%)