DRSC/TRiP Functional Genomics Resources

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Protein Alignment eg and AR

DIOPT Version :10

Sequence 1:NP_524206.1 Gene:eg / 40428 FlyBaseID:FBgn0000560 Length:373 Species:Drosophila melanogaster
Sequence 2:NP_000035.2 Gene:AR / 367 HGNCID:644 Length:920 Species:Homo sapiens


Alignment Length:103 Identity:39/103 - (37%)
Similarity:49/103 - (47%) Gaps:20/103 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 CKVCGEPAAGFHFGAFTCEGCKSFFGRTYNNIAAIAG-----CKHNGDCVINKKNRTACKACRLR 64
            |.:||:.|:|.|:||.||..||.||.|      |..|     |....||.|:|..|..|.:||||
Human   560 CLICGDEASGCHYGALTCGSCKVFFKR------AAEGKQKYLCASRNDCTIDKFRRKNCPSCRLR 618

  Fly    65 KCLLVGMSKSGSRYGRRSNWFKIHCLLQEQ----QTTS 98
            ||...||:....:..:..|     ..|||:    .|||
Human   619 KCYEAGMTLGARKLKKLGN-----LKLQEEGEASSTTS 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
egNP_524206.1 NR_DBD_like 3..87 CDD:413390 33/86 (38%)
ARNP_000035.2 Interaction with ZNF318. /evidence=ECO:0000250|UniProtKB:P19091 1..587 15/32 (47%)
Modulating 1..559
Androgen_recep 6..449 CDD:426632
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..167
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..228
Interaction with LPXN. /evidence=ECO:0000269|PubMed:18451096 552..919 39/103 (38%)
NR_DBD_AR 555..636 CDD:143547 32/81 (40%)
Interaction with HIPK3. /evidence=ECO:0000250|UniProtKB:P15207 572..662 33/91 (36%)
Interaction with CCAR1. /evidence=ECO:0000269|PubMed:23887938 592..919 22/65 (34%)
Interaction with KAT7. /evidence=ECO:0000269|PubMed:10930412 625..919 8/32 (25%)
NR_LBD_AR 673..918 CDD:132758
Blue background indicates that the domain is not in the aligned region.

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