Protein Alignment Syn1 and DLG5

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_004738.3
• Gene: DLG5 / 9231
• HGNCID: 2904
• Length: 1919
• Species: Homo sapiens
• Alignment Length: 396
• Identity: 91/396 - (22%)
• Similarity: 136/396 - (34%)
• Gaps: 146/396 - (36%)

  Fly     2 VESSSLG--RTPPAAQQPIPQQHSPSPSGLRCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEA 64
            |.|..:|  .:||||:...||...||          .:.:|              .:|||.|...
Human  1199 VRSHRVGPCSSPPAARDAGPQGLHPS----------VQHQG--------------RLSLDLSHRT 1239

  Fly    65 AQPSNDGQSTTLNGTLGSNHSGGGGGGAGGGGTGGGGQNGTLPNSASL-QGMNIQ---------- 118
            ....::     :..|.|||                     :||:||.| ...|:|
Human  1240 CSDYSE-----MRATHGSN---------------------SLPSSARLGSSSNLQFKAERIKIPS 1278

  Fly   119 ---------DTELDGSASNDNGDRDP-----------CLNNNNNAGD---------GGGMDMCDV 154
                     .:| .||.|:......|           |..:..:|..         ..|....|.
Human  1279 TPRYPRSVVGSE-RGSVSHSECSTPPQSPLNIDTLSSCSQSQTSASTLPRIAVNPASLGERRKDR 1342

  Fly   155 PDHVANQKRHVRIIKSDNNGLGISI----KGGRENRMPILISKIFRGMAADQAKGLYVGDAILTV 215
            |  ...:.|||::.|. :..|||||    |||      |.:||:..|..|.|| ||..||.:|..
Human  1343 P--YVEEPRHVKVQKG-SEPLGISIVSGEKGG------IYVSKVTVGSIAHQA-GLEYGDQLLEF 1397

  Fly   216 NGEELRDATHDEAVRALKRSGRVVDLEVKF---LREVTPYFRKASIISEVGWE--LQ-RAFLCPL 274
            ||..||.||..:|...:.:....:.:..::   :.:::.:.|.:|.:...|..  || .....|.
Human  1398 NGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSSSHLDPAGTHSTLQGSGTTTPE 1462

  Fly   275 GPGV----------PTSPPAPKTTPR--ADTRYIPLQLTHLARNLKYIDP-----ENRCFELHSP 322
            .|.|          |::|||.:::.|  .|.            |.|.::|     :....||
Human  1463 HPSVIDPLMEQDEGPSTPPAKQSSSRIAGDA------------NKKTLEPRVVFIKKSQLEL--- 1512

  Fly   323 DGVHSC 328
             |||.|
Human  1513 -GVHLC 1517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	4/30 (13%)
		PDZ_signaling	163..244	CDD:238492	31/84 (37%)
		PHsplit_syntrophin	<293..351	CDD:269960	9/41 (22%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863
		PDZ_signaling	620..707	CDD:238492
		DegQ	<702..771	CDD:223343
		PDZ_signaling	722..790	CDD:238492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	927..1122
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1150..1187
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1201..1230		11/52 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1245..1264		9/44 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1271..1306		5/35 (14%)
		PDZ	1347..1429	CDD:214570	31/89 (35%)
		dbPDZ_assoc	1427..1499	CDD:293216	16/83 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1434..1493		13/58 (22%)
		PDZ	1499..1582	CDD:214570	7/23 (30%)
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900