DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syn1 and MPDZ

DIOPT Version :9

Sequence 1:NP_001262192.1 Gene:Syn1 / 40424 FlyBaseID:FBgn0037130 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_001362342.1 Gene:MPDZ / 8777 HGNCID:7208 Length:2103 Species:Homo sapiens


Alignment Length:555 Identity:128/555 - (23%)
Similarity:205/555 - (36%) Gaps:154/555 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 GAGGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVP 155
            ||..|......|:..:|.|.|.:..:|::|....:         |.:..::.|       .|.: 
Human  1608 GAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSST---------PAIFASDPA-------TCPI- 1655

  Fly   156 DHVANQKRHVRIIKSDNNGLGISIKGGRENRM-PILISKIFRGMAADQAKGLYVGDAILTVNGEE 219
              :...:..:.|.|. ..|||:||.||.:..: .|:|.:::...||.:...|:.||.||.|||.:
Human  1656 --IPGCETTIEISKG-RTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1717

  Fly   220 LRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPA 284
            ||.||||||:..|:::.:.|.|.:  .|:..|| ::..:...:..|||:.   | |.|:..|   
Human  1718 LRKATHDEAINVLRQTPQRVRLTL--YRDEAPY-KEEEVCDTLTIELQKK---P-GKGLGLS--- 1772

  Fly   285 PKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVH-SCILRA--ADSAEALVWFNALH 346
             ....|.||                              ||. |.|::.  ||:...|:..:.:.
Human  1773 -IVGKRNDT------------------------------GVFVSDIVKGGIADADGRLMQGDQIL 1806

  Fly   347 SAMGTSTQRALAEANRAL--------TNLIGELKHIGWLSKRMSGGGSSGSAGGGAA----SGGS 399
            ...|...:.|..||..||        |..:|.:|...:.|:|.....|..|.|..::    ..||
Human  1807 MVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGS 1871

  Fly   400 GTSNSV--------VAGEL-----------------VSPSGRSSSESSDESDKWLPIFVAVTERE 439
            .||.|:        :|.|:                 :|.:|...|...|     :|||:|:..  
Human  1872 STSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGD-----VPIFIAMMH-- 1929

  Fly   440 FRIYESAPWSVEAWSRPLEIYALATTRLAGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETH 504
                   |..|.|.::.|.:.....| :.|.......:.|...:.....|:....:|        
Human  1930 -------PTGVAAQTQKLRVGDRIVT-ICGTSTEGMTHTQAVNLLKNASGSIEMQVV-------- 1978

  Fly   505 RDMAAWARSLVQGSHQAVNYQREFSF-----RCLFQG----RQCQLVVHINR-----GFFLYDCG 555
               |....|:|.| ||........||     ..:||.    .||:.:. :.|     ||.:  .|
Human  1979 ---AGGDVSVVTG-HQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSIT-LERGPDGLGFSI--VG 2036

  Fly   556 GF-APTTPTVATAKTQLWQFAFDKLKGSADDGARM 589
            |: :|........||   .||    ||:|.:..|:
Human  2037 GYGSPHGDLPIYVKT---VFA----KGAASEDGRL 2064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syn1NP_001262192.1 PH-like 30..>61 CDD:302622
PDZ_signaling 163..244 CDD:238492 32/81 (40%)
PHsplit_syntrophin <293..351 CDD:269960 8/60 (13%)
MPDZNP_001362342.1 PDZ_signaling 2019..2102 CDD:238492 14/56 (25%)
L27_2 6..63 CDD:312549
PDZ_signaling 139..221 CDD:238492
PDZ_signaling 257..334 CDD:238492
PDZ 374..463 CDD:214570
PDZ_signaling 560..629 CDD:238492
PDZ_signaling 698..784 CDD:238492
PDZ_signaling 1006..1076 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1140
PDZ_signaling 1149..1240 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1324
PDZ 1347..1433 CDD:214570
PDZ_signaling 1514..1593 CDD:238492
MPDZ_u10 1595..1659 CDD:374710 12/69 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1645 10/45 (22%)
PDZ 1660..1744 CDD:214570 32/86 (37%)
PDZ_signaling 1758..1836 CDD:238492 24/115 (21%)
PDZ_signaling 1893..1978 CDD:238492 16/99 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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