DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syn1 and Pard3

DIOPT Version :9

Sequence 1:NP_001262192.1 Gene:Syn1 / 40424 FlyBaseID:FBgn0037130 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_112514.1 Gene:Pard3 / 81918 RGDID:620374 Length:1337 Species:Rattus norvegicus


Alignment Length:624 Identity:124/624 - (19%)
Similarity:203/624 - (32%) Gaps:213/624 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SSLGRTPPAAQQP--IPQQHSPSPSGLRCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQP 67
            |.||....:|.:|  ...:...:||.|| .||...||.:....|..|.|   :|| |.:..:.:|
  Rat   106 SELGTNNVSAFRPYQTTSEIEVTPSVLR-ANMPLHVRRSSDPALTGLST---SVS-DNNFSSEEP 165

  Fly    68 S--NDGQSTTLNGTLGSNHSGGGGGGAGGGGTGGGGQN---------GTLPNSAS---------- 111
            |  |..:.:|..|.|..|             |.|..:.         .:||...|          
  Rat   166 SRKNPTRWSTTAGFLKQN-------------TTGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDN 217

  Fly   112 -----------------LQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVA 159
                             .|..:.:.||.|.|.....|..|..|.|..|      ..:.|:     
  Rat   218 ARSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPN------FSLDDM----- 271

  Fly   160 NQKRHVRIIKSDNNG--LGI-----SIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNG 217
                 |::::..|:|  |||     |.:|||  .:.:|:.::.:|..|:|....:..|.|:.:|.
  Rat   272 -----VKLVQVPNDGGPLGIHVVPFSARGGR--TLGLLVKRLEKGGKAEQENLFHENDCIVRIND 329

  Fly   218 EELRDATHDEAVRALKRS--GRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPT 280
            .:||:...::|....:::  .||:..      .|.|...|     |...:|.:..:....|| ..
  Rat   330 GDLRNRRFEQAQHMFRQAMRARVIWF------HVVPAANK-----EQYEQLSQREMNNYSPG-RF 382

  Fly   281 SPP------------APKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAA 333
            ||.            ||:..|||.....|              ||.  .:.| |...||.     
  Rat   383 SPDSHCVANRSVANNAPQALPRAPRLSQP--------------PEQ--LDAH-PRLPHSA----- 425

  Fly   334 DSAEALVWFNALHSAMGTSTQRALAEANRALTNLIGELKHIGWLSKRMSGGGSSGSAG------- 391
                        |::....|..|||..| .|:..:|.:.:...:.||::.....|:.|       
  Rat   426 ------------HASTKPPTAPALAPPN-VLSTSVGSVYNTKRVGKRLNIQLKKGTEGLGFSITS 477

  Fly   392 -----GGAA---------SGGSGTSNSVVAGEL------VSPSGRSSSE-----SSDESDKWLPI 431
                 ||:|         .|.:.....:.||:.      |..:|:|..|     .|.:.:..:.:
  Rat   478 RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSL 542

  Fly   432 FVAVTEREFRIYE--------SAPWSVEA----------WSRPLEIYALATTRLAGAGNNSSLNG 478
            .|...|..|...|        .:|...:|          .:|....:.:.......||...|:.|
  Rat   543 LVFRQEEAFHPREMNAEPSQMQSPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKG 607

  Fly   479 QQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQG 517
            .::                   .|.|.|:..:.:|::.|
  Rat   608 NRS-------------------KENHADLGIFVKSIING 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syn1NP_001262192.1 PH-like 30..>61 CDD:302622 11/30 (37%)
PDZ_signaling 163..244 CDD:238492 22/89 (25%)
PHsplit_syntrophin <293..351 CDD:269960 8/57 (14%)
Pard3NP_112514.1 DUF3534 1..146 CDD:288873 13/40 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..109 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..263 26/136 (19%)
PDZ_signaling 272..347 CDD:238492 20/76 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..441 17/77 (22%)
PDZ_signaling 465..544 CDD:238492 13/78 (17%)
PDZ_signaling 588..681 CDD:238492 9/59 (15%)
Interaction with PRKCI and PRKCZ. /evidence=ECO:0000269|PubMed:9763423 712..936
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 866..888
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 932..1015
Interaction with FRMD4A. /evidence=ECO:0000250|UniProtKB:Q99NH2 935..1337
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1055
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1110..1271
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1337
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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