DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and Grip1

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	609	Identity:	136/609 - (22%)
Similarity:	216/609 - (35%)	Gaps:	185/609 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGGGGTGGGGQNGTLPNSAS 111
            ||||.:|      :..|:..||    |.|.:..|...||...|              .|:.:.:|
Mouse   609 VTLEIEF------DVAESVIPS----SGTFHVKLPKKHSVELG--------------ITISSPSS 649

  Fly   112 LQ---GMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVANQKR-----HVRII 168
            .:   .:.|.|.: .||.::..|..:  |.:...|.|...:|.|.:.|.|...::     .::|.
Mouse   650 RKPGDPLVISDIK-KGSVAHRTGTLE--LGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIR 711

  Fly   169 KSDNNG---------------------LGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAI 212
            |.::|.                     |||:|.|..|...||:||.:.:|..|::...:::||.|
Mouse   712 KDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRI 776

  Fly   213 LTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREV----TPYFRKASIISEVGWELQRAFLCP 273
            |.:|...|:.....||:..|:.:|..|.|::|...:.    :|  :|..|....|         .
Mouse   777 LAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSP--KKFPIPGHSG---------D 830

  Fly   274 LGPG----VPTSPPA------PKTTPRADTRY--------------------------------I 296
            ||.|    .|...|.      |.|.|..|:..                                .
Mouse   831 LGDGEEDPSPIQKPGKLSDAYPSTVPSVDSAVDSWDGSGIDASYGSQGSTFQTSGYNYNTYDWRS 895

  Fly   297 PLQLTHLA-----RNLKYIDP--ENRCFELHSPDGVHSCILRAADSAEA----LVWFNALHSAMG 350
            |.|.|.|:     |:..|.|.  .|..::..:..|    .:.|:|||:|    ..|..||.. :.
Mouse   896 PKQRTSLSPVPKPRSQTYPDVGLSNEDWDRSTASG----FVGASDSADAEQEENFWSQALED-LE 955

  Fly   351 TSTQ----RALAE-ANRALTNLIGELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGEL 410
            |..|    |.|.| |:|.::     |:::..|:..|||...|.:.....|....|...|......
Mouse   956 TCGQSGILRELEEKADRRVS-----LRNMTLLATIMSGSTMSLNHEAPMARSQLGRQASFQERSS 1015

  Fly   411 VSP----SGRSSSESSDESDKWLPIFVAVTEREFR--IYE-SAPWSVEAWSRPLEIYALATTRLA 468
            ..|    :.||::..||...|      :||.|:.:  |.| .:|       .|:|::.:...:
Mouse  1016 SRPHYSQTTRSNTLPSDVGRK------SVTLRKMKQEIKEIMSP-------TPVELHKVTLYK-- 1065

  Fly   469 GAGNNSSLNGQQTTVFCVRCG-TARGVLVYWLRSETHRDMAA---WARSLVQGSHQAVNYQREFS 529
                   .:|.:...|.|..| ..:||.|..:|.....|:..   :.|.|      .||:.|...
Mouse  1066 -------DSGMEDFGFSVADGLLEKGVYVKNIRPAGPGDVGGLKPYDRLL------QVNHVRTRD 1117

  Fly   530 FRCLF-------QGRQCQLVVHIN 546
            |.|..       .|.:..||:..|
Mouse  1118 FDCCLVVPLIAESGNKLDLVISRN 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	5/13 (38%)
		PDZ_signaling	163..244	CDD:238492	27/106 (25%)
		PHsplit_syntrophin	<293..351	CDD:269960	17/100 (17%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492
		PDZ_signaling	209..292	CDD:238492
		PDZ_signaling	307..390	CDD:238492
		PDZ_signaling	526..614	CDD:238492	4/4 (100%)
		PDZ_signaling	627..711	CDD:238492	19/100 (19%)
		PDZ_signaling	727..808	CDD:238492	24/80 (30%)
		PDZ_signaling	1058..1138	CDD:238492	18/94 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900