Protein Alignment Syn1 and Sntb2

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_001162145.1
• Gene: Sntb2 / 689421
• RGDID: 1592340
• Length: 522
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 228/613 - (37%)
• Similarity: 315/613 - (51%)
• Gaps: 125/613 - (20%)

  Fly    30 RCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGG 94
            :.|.:|..:|..|.||:..|..:.|:::.|.:....:|    .:...||.    .:||||||
  Rat     9 KAGLVELLLRERWVRVVAELSGESLSLTGDAAAVEPEP----PAVAFNGL----PNGGGGGG--- 62

  Fly    95 GGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVA 159
                                     ..|.||.:...|...|.......||:..          .:
  Rat    63 -------------------------DSLPGSPNRGLGPPSPPAPPRGPAGEAS----------AS 92

  Fly   160 NQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDAT 224
            ...|.||::|.:..||||||||||||||||||||||.|:||||::.|.:|||||:|||.:||.||
  Rat    93 PPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQAT 157

  Fly   225 HDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPT--------S 281
            ||:||:||||:|:.|.|||||:||||||.:|.|::|::.||       ...|..|:        |
  Rat   158 HDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWE-------GASPQSPSFSGSEDSGS 215

  Fly   282 PPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALH 346
            |....||  .|.:.|||::...||||...|.|||..||||||..::.|||..|:|.|..||.|:|
  Rat   216 PKHQNTT--KDRKVIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIH 278

  Fly   347 SAMGTSTQRALAEANRAL--TNLIG---ELKHIGWLSK--RMSGGGSSGSAGGGAASGGSGTSNS 404
            :.:.....:.|||.|..|  |:..|   |:|||.||::  ::.||
  Rat   279 TNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGG-------------------- 323

  Fly   405 VVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRL-- 467
                                ..:|.|:.:||||::..:|:..||:.:||:.|...|.|..|||
  Rat   324 --------------------RQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVH 368

  Fly   468 AGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFRC 532
            :|:|..|...|...| |..|.|:.:|:.::..|.|||||::.|.|.||||.|.|....:|.|..|
  Rat   369 SGSGCRSPSLGSDLT-FATRTGSRQGIEMHLFRVETHRDLSTWTRILVQGCHAAAELIKEVSLGC 432

  Fly   533 LFQGRQCQLVVHINRGFFL-YDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDF-G 595
            ...|:..:..||...||.: .|.||    |.::      |:::.|::||.|||||.|.||||| |
  Rat   433 TLSGQDVRFTVHYEHGFTITRDNGG----TSSI------LYRYPFERLKMSADDGIRNLYLDFGG 487

  Fly   596 EDGEIELDMECCPKPVVFVVHNCLSAKV 623
            .:||:.:|:..||||:|||:|..|||||
  Rat   488 PEGELTMDLHSCPKPIVFVLHTFLSAKV 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	9/30 (30%)
		PDZ_signaling	163..244	CDD:238492	56/80 (70%)
		PHsplit_syntrophin	<293..351	CDD:269960	27/57 (47%)
Sntb2	NP_001162145.1	PDZ_signaling	95..177	CDD:238492	56/81 (69%)
		PHsplit_syntrophin	<226..283	CDD:269960	27/56 (48%)
		PH	308..419	CDD:278594	45/151 (30%)
		PH	319..419	CDD:214574	40/140 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337654
Domainoid	1	1.000	157	1.000	Domainoid score	I4080
eggNOG	1	0.900	-	-		E1_KOG3551
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	384	1.000	Inparanoid score	I1963
OMA	1	1.010	-	-		QHG45230
OrthoDB	1	1.010	-	-		D1261897at2759
OrthoFinder	1	1.000	-	-		FOG0003604
OrthoInspector	1	1.000	-	-		otm45137
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10554
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870