Protein Alignment Syn1 and Pdzd2

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_001074533.1
• Gene: Pdzd2 / 68070
• MGIID: 1922394
• Length: 2796
• Species: Mus musculus
• Alignment Length: 526
• Identity: 110/526 - (20%)
• Similarity: 186/526 - (35%)
• Gaps: 150/526 - (28%)

  Fly     4 SSSLGRTPPAAQQPIPQQHSPSPSGLRCGNMETRVRGAWYRVLVTLETDFLAVSLDES-----CE 63
            ||..|.||.                |..|: :|..:|...|....:....:..:.::|     |:
Mouse   194 SSEPGETPT----------------LELGD-QTSKKGKRTRKFGVISRPAIIKAPEDSKSNSGCD 241

  Fly    64 AAQPSNDGQSTTLNGT---LGSNHSGGGGGGAGGGGTGGGGQNGTLPNS-ASLQGMNIQDTELDG 124
            .|   :|..|...|||   ||:.|:             ...:||  ||| ..:.|.:::.:|.|.
Mouse   242 TA---DDPSSELENGTDSELGNGHA-------------FELENG--PNSLKDVAGPHLERSEADR 288

  Fly   125 SASNDNGDRDPCLNNNNNAG--DGGGMDMCDVPDHVANQKRHVRIIK----SDNNGLGISIKGGR 183
            .|.......:..|:::|:..  ...|.......|.:|.::.. ||.|    .:::||||.:.|||
Mouse   289 EAELRVPKTEAPLSDSNDKRRFSKTGKTNFQSSDSLAREEVG-RIWKMELLKESDGLGIQVSGGR 352

  Fly   184 -ENRMP--ILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKF 245
             ..|.|  |:::::..|.||.:...|.:||.:|.:||..|...:|:|||..|:.:..:|.|.|
Mouse   353 GSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVV-- 415

  Fly   246 LREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPAPKTTPRAD-----TRYIPLQLTHLAR 305
                                                  |.|.:...|     ::.:| .||....
Mouse   416 --------------------------------------ASKESSAEDLLKLTSKSLP-DLTSSVE 441

  Fly   306 NL-KYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALHSAMGTSTQRALAEANRALTNLIG 369
            :: .:.|.|::.......:|..|..:|.              :.:|:...:.:..:..:..|.:.
Mouse   442 DISSWTDNEDQEAARDDEEGTGSAAVRG--------------TMLGSEESQDVGSSEESKGNNLE 492

  Fly   370 ELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVA-GELVSPSG----RSSSESSDESDKWL 429
            ..|.           |:|........|||.....||.. .||:..:|    |....|.|.....|
Mouse   493 SPKQ-----------GNSKMKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSL 546

  Fly   430 PIFV--AVTEREFRI-----------YESAPWSVEAWSRPLEIYALATTRLAGAGNNSSLNGQQT 481
            |..:  ..|.:|:.|           :..:||.:   .||..|..:...:..|.|...|:.|.:.
Mouse   547 PQLLDSTGTSQEYHIVKKSTRSLSTTHVESPWRL---IRPSVISIIGLYKEKGKGLGFSIAGGRD 608

  Fly   482 TVFCVR 487
               |||
Mouse   609 ---CVR 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	4/30 (13%)
		PDZ_signaling	163..244	CDD:238492	30/87 (34%)
		PHsplit_syntrophin	<293..351	CDD:269960	8/58 (14%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492	28/120 (23%)
		PDZ_signaling	591..672	CDD:238492	7/24 (29%)
		PDZ_signaling	729..813	CDD:238492
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900