DRSC/TRiP Functional Genomics Resources

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Protein Alignment Syn1 and SNTA1

DIOPT Version :9

Sequence 1:NP_001262192.1 Gene:Syn1 / 40424 FlyBaseID:FBgn0037130 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_003089.1 Gene:SNTA1 / 6640 HGNCID:11167 Length:505 Species:Homo sapiens


Alignment Length:609 Identity:209/609 - (34%)
Similarity:307/609 - (50%) Gaps:134/609 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 RCGNMETRV---RGA----WYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGG 87
            |.|.:|.|.   .||    |.|||::|..|.|.||         |::                  
Human     9 RTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVS---------PAD------------------ 46

  Fly    88 GGGGAGGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMC 152
                         |..|..|.:...|    :..:|:|:|       :|          |.|..  
Human    47 -------------GDPGPEPGAPREQ----EPAQLNGAA-------EP----------GAGPP-- 75

  Fly   153 DVPDHVANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNG 217
            .:|:.:..|:|.|.:.|:|..||||||||||||:|||||||||:|:||||.:.|:||||||:|||
Human    76 QLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNG 140

  Fly   218 EELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSP 282
            |:|..|||||||:.||::|:.|.||||::::|:|||:.::..:.|||:..     |..| :...|
Human   141 EDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSP-----PASP-LQRQP 199

  Fly   283 PAPKTTPR--ADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNAL 345
            .:|..|||  ::.:::.|::.::::.....|||.|..|:.|.||..:..|||.|.|.|..|..|:
Human   200 SSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAI 264

  Fly   346 HSAMGTSTQRALAE--ANRALTNLIG--ELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVV 406
            .:.:.|.|.|...|  |..|.|:..|  ::|.||||::::..||::                   
Human   265 QAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTA------------------- 310

  Fly   407 AGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRLAGAG 471
                                   |....:||:|..:|.|.|.:.||.|||.....|..|||..:|
Human   311 -----------------------PTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSG 352

  Fly   472 -NNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFRCLFQ 535
             :..|:.......|.:|.||..||..:....|:.:::|||.|.||.|.|:|....:|.|..|.:.
Human   353 PSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWN 417

  Fly   536 GRQCQLVVHINRGFFLYDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDF-GEDGE 599
            ||.|.|.|||::||.|:        ......|:..|.:..|:||:.|:||||.:|:||| |.:||
Human   418 GRPCSLSVHIDKGFTLW--------AAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGE 474

  Fly   600 IELDMECCPKPVVFVVHNCLSAKV 623
            |:||:..|||.:||::|:.|||||
Human   475 IQLDLHSCPKTIVFIIHSFLSAKV 498

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syn1NP_001262192.1 PH-like 30..>61 CDD:302622 15/37 (41%)
PDZ_signaling 163..244 CDD:238492 55/80 (69%)
PHsplit_syntrophin <293..351 CDD:269960 17/57 (30%)
SNTA1NP_003089.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25 6/15 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..77 14/99 (14%)
PDZ_signaling 86..167 CDD:238492 55/80 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..210 10/35 (29%)
PHsplit_syntrophin <209..270 CDD:269960 17/60 (28%)
PH 298..401 CDD:278594 37/144 (26%)
PH 298..401 CDD:214574 37/144 (26%)
Calmodulin-binding. /evidence=ECO:0000250 483..505 10/16 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143875
Domainoid 1 1.000 117 1.000 Domainoid score I5914
eggNOG 1 0.900 - - E1_KOG3551
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 391 1.000 Inparanoid score I2000
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45230
OrthoDB 1 1.010 - - D1261897at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41001
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10554
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1403
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.870

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