DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and lnx2b

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	257	Identity:	60/257 - (23%)
Similarity:	103/257 - (40%)	Gaps:	69/257 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QPIPQQHS------PSPSGLRCGNMETRVRGAWYRVLVTL----ETDFLAVSLDESCEAAQP--- 67
            :|.|:.|:      |:.|.....|..|.::       |||    .::.|.:.|....|  :|
Zfish   298 KPRPEHHTQPSASPPTQSPSTNQNHGTVIQ-------VTLVKHERSEALGIKLIRKSE--EPGVF 353

  Fly    68 ----------SNDGQSTTLNGTLGSNHSGGGGGGAGGGGTGGGGQNGTLPNSAS--LQG------ 114
                      :.||:....:..||.|              |...::|| |.||:  :|.
Zfish   354 ILDLLPGGLAAKDGKLRNNDKVLGIN--------------GQDLRHGT-PESAAQIIQASEMRVN 403

  Fly   115 ---MNIQDTELDGSASNDNGDR---DPCLNNNNNAGDGGGMDMCDVPDHVANQKRHVRIIKSDNN 173
               |.:||...:|......|.|   :|.....::.      .|.:.|...::|::.|.:.|....
Zfish   404 FVVMRLQDVSEEGGEGQSRGARRVPEPQYFRRHSE------YMKEPPGGFSSQEKTVTLKKEPRQ 462

  Fly   174 GLGISIKGGRE--NRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALK 233
            .|||:|.|||:  :|:|:.|:.:.......:...:..||.:|::||.:|...|::|||..||
Zfish   463 SLGITIAGGRDCRSRLPVYITSVQPVGCLHRDGTVKTGDVLLSINGIDLTHLTYNEAVTVLK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	7/34 (21%)
		PDZ_signaling	163..244	CDD:238492	24/73 (33%)
		PHsplit_syntrophin	<293..351	CDD:269960
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492
		PDZ_signaling	325..406	CDD:238492	19/104 (18%)
		PDZ_signaling	451..537	CDD:238492	24/74 (32%)
		PDZ_signaling	587..671	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900