DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and PARD3

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_062565.2	Gene:	PARD3 / 56288	HGNCID:	16051	Length:	1356	Species:	Homo sapiens

Alignment Length:	127	Identity:	38/127 - (29%)
Similarity:	57/127 - (44%)	Gaps:	17/127 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 SDNNGLGISIKGGR--ENR--MPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVR 230
            |.:.|||:|:||.|  ||.  :.|.:..|..|.||.:...|.|.|.::.||||.|...|:.:|:.
Human   596 SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME 660

  Fly   231 ALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPAPKTTPRAD 292
            .|:||......:...::.:..  |:.|..:|:           ..||.|..|..|..|...|
Human   661 TLRRSMSTEGNKRGMIQLIVA--RRISKCNEL-----------KSPGSPPGPELPIETALDD 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	28/77 (36%)
		PHsplit_syntrophin	<293..351	CDD:269960	38/127 (30%)
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..262
		PDZ_signaling	272..347	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..448
		PDZ_signaling	465..544	CDD:238492
		PDZ_signaling	588..681	CDD:238492	28/84 (33%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250\|UniProtKB:Q9Z340	712..936
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..886
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1025
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1356
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900