DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and Tamalin

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_062391.3	Gene:	Tamalin / 56149	MGIID:	1860303	Length:	392	Species:	Mus musculus

Alignment Length:	296	Identity:	64/296 - (21%)
Similarity:	103/296 - (34%)	Gaps:	67/296 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GGGMDMCDVPDHVANQKRHVRIIKSDNNGLGISIKG-GRENR------MPILISKIFRGMAADQA 203
            |.|....:.......|::.:.:.|.||...|..|:. |..:|      |...:.::.....| |.
Mouse    82 GSGFRWKNFTQSPEQQRKVLTLEKGDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPA-QL 145

  Fly   204 KGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQR 268
            .||..||.|.:|||..:....|.|.|..:|.||.|:.||..:...:    |||.:.:.:.:..|.
Mouse   146 AGLTPGDTIASVNGLNVEGIRHREIVDIIKASGNVLRLETLYGTSI----RKAELEARLQYLKQT 206

  Fly   269 AFLCPLGPGVPTSPPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAA 333
            .:                 ....:.|.:.:|...|...|...||.    ...:.:.|.||:..|.
Mouse   207 LY-----------------EKWGEYRSLMVQEQRLVHGLVVKDPS----IYDTLESVRSCLYGAG 250

  Fly   334 DSAEALVWFNALHSAMGTS---TQRALAEANRAL--TNLIG------------ELKHIGWLS--- 378
            ....:|. |..|.:|.|::   .:||..:.:.|:  |...|            ..:.:|..|
Mouse   251 LLPGSLP-FGPLLAAPGSARGGARRAKGDTDDAVYHTCFFGGAEPQALPPPPPPARALGPSSAET 314

  Fly   379 -------------KRMSGGGSSGSAGGGAASGGSGT 401
                         .|.:....:|..|||.|.|...|
Mouse   315 PASVLFPAPRSTLSRSASVRCAGPGGGGGAPGALWT 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	27/87 (31%)
		PHsplit_syntrophin	<293..351	CDD:269960	14/57 (25%)
Tamalin	NP_062391.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		PDZ_signaling	99..184	CDD:238492	25/85 (29%)
		Interaction with PSCD3. /evidence=ECO:0000269\|PubMed:10828067	180..257		17/101 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315		2/20 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900