DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn1 and lnx1

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_005160562.1	Gene:	lnx1 / 561226	ZFINID:	ZDB-GENE-030131-9439	Length:	769	Species:	Danio rerio

Alignment Length:	683	Identity:	132/683 - (19%)
Similarity:	211/683 - (30%)	Gaps:	238/683 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PSGLRCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQST--TLNGTLGSNHSGGG 88
            |.|...|::..|.:||.:..|              |.|..:.|.:|..|  |...||.:....|.
Zfish   132 PRGEMEGHIRCRCKGASHYGL--------------SAERKRRSQEGDCTDSTSELTLAALPGEGC 182

  Fly    89 GGGA------------------------GGGGTGGGGQNG-----------TLPNSASLQGMN-- 116
            ...|                        .|..|....::|           |...|.|.:.:|
Zfish   183 PSSAIALLSDEPGLVNPAYEPSVEDNSQSGSTTSLAARSGSRKSEYRNFDRTSVRSRSFRRLNRA 247

  Fly   117 ---IQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCD----VPDHVANQKRHVRIIKSDN-N 173
               ::.|:...:.:||..:....|.|.|...:|....:..    :||   .:...::|.::|. .
Zfish   248 FSVLRRTKSGTAVANDTTEERDNLRNANIPAEGELFALPQLHHLIPD---GEVTSIKITRADPCE 309

  Fly   174 GLGISIKGGRENRM-PILISKIFR-GMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSG 236
            .|.|||.||.|..: .|||..|:| |:.|...: |..||.||.|||.::.:..|..||.|||:..
Zfish   310 PLAISIVGGNETPLVRILIQDIYREGVIARDGR-LLPGDMILKVNGIDISNVPHCYAVAALKQPC 373

  Fly   237 RVVDLEVKFLREVTPYFR---------------------------KASIISEVGWELQR------ 268
            .::.|.|  |||....:|                           |.:...::|.:|.|
Zfish   374 TLLRLTV--LREQRHRYRSHHHSPTEAFPAHTATIRDDSLHVVLVKRAPDEQLGIKLVRRPDEHG 436

  Fly   269 AFLCPLGPGVPTSPPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELH-SPDGVHSCILR- 331
            .|:..|..|   ...|.....|.|.|.:.:.    ..:|:|..||:....:. |.|.||..:.|
Zfish   437 VFIFHLLEG---GLAARDGRLRVDDRVLAIN----GHDLRYGAPEHAALLIQASEDRVHFIVSRQ 494

  Fly   332 ----AADSAEALVW----------FNALHSAMGTSTQRALAEANRAL---------TNLIGELKH 373
                |.|..:...|          .:..|:.:.:..:.|..|....|         ..:.|.:..
Zfish   495 THIPAPDILQEAPWNMEGPPPYSPVDIEHTLLDSCQKPACYEKTVTLLKEPHDSLGMTVAGGMSS 559

  Fly   374 IGW-------------------------LSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGEL--- 410
            .||                         :...::|...:|.....|.:....||:.||...|
Zfish   560 RGWDLPVYVTNVDPNGVVGQEGSIRKGDILLNVNGVDLTGVTRSEAVANLKNTSSPVVLQVLEMR 624

  Fly   411 ------------------VSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSR-P 456
                              :|||.....:....:|.:.|::|                  :|.: |
Zfish   625 PPNESSLDCMPPLHSPCALSPSSPGDVKLPPPNDDYAPLWV------------------SWLQLP 671

  Fly   457 LEIYA---LATTRLAGAGNNSSLNGQQTTVFC--------------------VRCG--------- 489
            ..:|.   :...|........|:.|.|..:.|                    :|||
Zfish   672 RHLYCCKDIVLRRSTSGSLGFSIVGGQEELNCNQSFFIRSIVEGTPAYNDGRIRCGDILLEVNGK 736

  Fly   490 -------TARGVLVYWLRSETHRDMAAWARSLV 515
                   ||...|:..||......:.:|..||:
Zfish   737 STWGMTHTALVRLLKELRGRITLTIVSWPGSLL 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	5/30 (17%)
		PDZ_signaling	163..244	CDD:238492	31/83 (37%)
		PHsplit_syntrophin	<293..351	CDD:269960	14/73 (19%)
lnx1	XP_005160562.1	RING	57..93	CDD:214546
		PDZ_signaling	297..381	CDD:238492	32/86 (37%)
		PDZ_signaling	411..491	CDD:238492	19/86 (22%)
		PDZ_signaling	536..621	CDD:238492	12/84 (14%)
		DegQ	<548..621	CDD:223343	10/72 (14%)
		PDZ_signaling	678..762	CDD:238492	13/83 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810