DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and lnx2a

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001106696.2	Gene:	lnx2a / 553331	ZFINID:	ZDB-GENE-060228-2	Length:	737	Species:	Danio rerio

Alignment Length:	654	Identity:	128/654 - (19%)
Similarity:	199/654 - (30%)	Gaps:	228/654 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PPAAQQPIPQQHSPSP--SGLRCGNM-------------------ETRVRG---AWYRVLVTLET 51
            ||.:.|...::.:|||  ....|.|:                   |..|.|   |..||...|..
Zfish   163 PPKSPQTEIKEDTPSPPAGSNACNNVPTWTEEPGIDNPAFEESTEEDSVHGLECALPRVKRPLSN 227

  Fly    52 ----------------DF---LAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGGGGT 97
                            ||   |.:|.:|.|.......:|:.||:.....:.:|..|....||
Zfish   228 PCIHLLRTGSSASSGWDFVETLPLSAEEGCVKLPSLPEGEITTIEVHRTNPYSEMGISIVGG--- 289

  Fly    98 GGGGQNGTLPNSASLQGMNIQDTELDGSASNDN----GDRDPCLNNNNNAGDGGGMDMCDVPDH- 157
                      |...|..:.||:...||..:.|.    ||:...:||         :|:.:||.:
Zfish   290 ----------NETPLINVVIQEVYRDGVIARDGRLLAGDQILQVNN---------VDISNVPHNF 335

  Fly   158 ---------------VANQKR-----------------HVRII---KSDNNGLGISIKGGRENRM 187
                           |..::|                 .:||.   :..:..|||.:....:...
Zfish   336 ARSTLARPCATLQLTVLRERRCSARPPAATASPKGSPASIRITLHKRESSEQLGIKLVRRTDEAG 400

  Fly   188 PILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPY 252
            ..::..:..|:||...: |...|.:|.||..:||..|.:.|.:.::.||..|:|.:....:.|..
Zfish   401 VFILDLLEGGLAAKDGR-LCSNDRVLAVNEHDLRHGTPELAAQIIQASGERVNLLISRSSKQTMA 464

  Fly   253 FRKASIISEVGWELQRAFLCPLGPGVPTSPPAPKT-TPRADTRYIPLQLTHLARNLKYIDPEN-- 314
            ....|.::...|.....            ||.|.| ||.      |:...||||:....|...
Zfish   465 VHTGSTLTRDIWSHDHI------------PPLPSTATPS------PVPSLHLARSSTQRDLSQCV 511

  Fly   315 RCFELH-----SPDGVHSCILRAADSAEALVWFNALHSAMGTSTQRALAEANRALTNLIGELKHI 374
            .|.|.|     .|                       |.::|.:........:..|...:..::..
Zfish   512 NCKEKHITVKKEP-----------------------HESLGMTVAGGRGSKSGELPIFVTSVQPH 553

  Fly   375 GWLSK--RMSGGGSSGSAGG--------GAASG---GSGTSNSV--------------VAGELVS 412
            |.||:  |:..|....|..|        ..|.|   .|.||.||              :..||:.
Zfish   554 GCLSRDGRIKRGDVLLSINGQDLTYLSHSEAVGTLKSSATSCSVQLKALEVTMVEEPGLDEELLP 618

  Fly   413 PSGRSSSESSDESDKWLPIFV--------AVTEREFRIYESAPWSVEAWSRP------------- 456
            |      ..:|....|.|.:|        ..:..|..:..|.|.|   |...
Zfish   619 P------HENDYDASWSPSWVLWLGLPSYLHSSHEIVLRRSHPGS---WGFSIVGGYEENHSNQA 674

  Fly   457 --LEIYALATT-----RLAGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHR---DMAAWA 511
              ::...|.|.     ||.......::||..|      .|.:...||..|:.:..|   .:.:|.
Zfish   675 FFIKTIVLGTPAYYDGRLKCGDMIVAVNGLST------AGMSHSALVPMLKEQRSRVALTVVSWP 733

  Fly   512 RSLV 515
            .||:
Zfish   734 GSLI 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	13/71 (18%)
		PDZ_signaling	163..244	CDD:238492	22/100 (22%)
		PHsplit_syntrophin	<293..351	CDD:269960	11/64 (17%)
lnx2a	NP_001106696.2	zf-RING_2	49..87	CDD:290367
		PDZ	267..353	CDD:214570	21/107 (20%)
		PDZ_signaling	375..455	CDD:238492	21/80 (26%)
		PDZ_signaling	515..600	CDD:238492	20/107 (19%)
		PDZ_signaling	646..730	CDD:238492	17/92 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900