DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and PDZK1

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_024303384.1	Gene:	PDZK1 / 5174	HGNCID:	8821	Length:	539	Species:	Homo sapiens

Alignment Length:	343	Identity:	75/343 - (21%)
Similarity:	119/343 - (34%)	Gaps:	93/343 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IPQQHSPS-PSGLRCGNMETRVRGAWYRVLVTLETDFLAVSL---------------DESCEAAQ 66
            :.::.||: .:||:.|:...|:.|    |.|..|.....|.|               |...:|.:
Human    57 VVEKCSPAEKAGLQDGDRVLRING----VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAVK 117

  Fly    67 PSND----GQSTT---LNGTLGSNHSGGG---------------GGGAGGGGTGGGGQNGTLPNS 109
            ...|    |||..   |:..:.|....||               ||..|.......|:.|.....
Human   118 TRVDLKELGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTD 182

  Fly   110 ASLQGMNIQ------DTELDGSASN-DNGDRDPCLNNNNNAGDGGGMDMCDVPDHVANQKRHV-- 165
            .:.||:.::      |..::.:..| ::...:..:.....:|......:.|    ....||||
Human   183 ITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVD----KETDKRHVEQ 243

  Fly   166 ------------------RII--KSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGD 210
                              ||:  |..:||.|..::.|.|.:..| |..|..|..|::| ||...|
Human   244 KIQFKRETASLKLLPHQPRIVEMKKGSNGYGFYLRAGSEQKGQI-IKDIDSGSPAEEA-GLKNND 306

  Fly   211 AILTVNGEELRDATHDEAVRALKRSG-----RVVDLEVKFLREVTPYFRKASIISEVGWELQRAF 270
            .::.||||.:....||..|..:::.|     .|||      :|....:|.|.....:.::.|.
Human   307 LVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVD------KETDNMYRLAHFSPFLYYQSQE-- 363

  Fly   271 LCPLGPGVPTSPPAPKTT 288
               |..|.....|||..|
Human   364 ---LPNGSVKEAPAPTPT 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	9/45 (20%)
		PDZ_signaling	163..244	CDD:238492	31/107 (29%)
		PHsplit_syntrophin	<293..351	CDD:269960
PDZK1	XP_024303384.1	PDZ_signaling	27..107	CDD:238492	12/53 (23%)
		PDZ	152..232	CDD:214570	10/79 (13%)
		PDZ_signaling	261..340	CDD:238492	25/80 (31%)
		PDZ	395..475	CDD:214570
		F1-ATPase_gamma	<457..>501	CDD:320933
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900