Protein Alignment Syn1 and sntb1

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_001002175.1
• Gene: sntb1 / 431722
• ZFINID: ZDB-GENE-040704-13
• Length: 515
• Species: Danio rerio
• Alignment Length: 617
• Identity: 220/617 - (35%)
• Similarity: 318/617 - (51%)
• Gaps: 136/617 - (22%)

  Fly    31 CGN-------METRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGG 88
            |||       :|..||..|:.||.:|..:    ||..|||  .|:.| .|.:|||..
Zfish     4 CGNRVQKSACLEVLVREQWHAVLASLGDE----SLTLSCE--DPAAD-TSVSLNGIT-------- 53

  Fly    89 GGGAGGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCD 153
                         .||:.             .:.|.:.|...|.|.|..::             .
Zfish    54 -------------TNGSY-------------DQPDPTNSPKTGARTPFSDS-------------Q 79

  Fly   154 VPDHVANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGE 218
            ||:.:||:||.|::||.:..|||||||||:||:|||||||||:|:||||.:.||||||||:|||.
Zfish    80 VPEAIANRKRCVKVIKQEVGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGI 144

  Fly   219 ELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGP--GVP-- 279
            .||||||||||:.||::|:.|.||||::||.|||.:|.|.:||:|||...    |..|  |.|
Zfish   145 NLRDATHDEAVQVLKKAGKEVMLEVKYMREATPYVKKGSPVSEIGWETPP----PESPRLGSPHF 205

  Fly   280 TSPPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNA 344
            ..|..|....:.|.|.|||::.::.|::...|||||..||||.|..::.::|..||:.|..||..
Zfish   206 ELPSPPSQCLQGDRRCIPLKMCYITRSMTVPDPENRQVELHSSDAKNTIVMRHTDSSSAQTWFTL 270

  Fly   345 LHSAMGTSTQRALAE----ANRALTNLIG--ELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSN 403
            :.|.:...|.:.::|    |.|  ..:||  |::|:|||:::
Zfish   271 MQSVITNLTNKVISELREHAGR--HGIIGSREIRHLGWLAEK----------------------- 310

  Fly   404 SVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRL- 467
                             :..|...|.|:.|.:||::..:::|.|...|.|..|...|.|..|||
Zfish   311 -----------------TESERQSWKPVLVMLTEKDLLLFDSMPRMREHWLTPTHTYPLLATRLV 358

  Fly   468 -AGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFR 531
             :|....|...|.:.: |..|.||..|:..:..|:||.:|::.|.|.:|.|.|.:....:|.:..
Zfish   359 HSGPDKGSPQPGGELS-FATRTGTRLGIEAHLFRAETCKDLSLWTRHIVTGCHTSAEMIKEVTTS 422

  Fly   532 CLFQGRQCQLVVHINRGFFLY----DCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYL 592
            |::||:.|:||:|..|||.:.    :|....|           |:.:.|::|:.|||||.|:|||
Zfish   423 CMYQGQDCRLVIHYERGFSVVAEGEECSRAEP-----------LFSYPFERLRMSADDGVRILYL 476

  Fly   593 DF-GEDGEIELDMECCPKPVVFVVHNCLSAKV 623
            || |.:|||:||:..||||:||::|:.||||:
Zfish   477 DFGGNEGEIQLDLHSCPKPIVFILHSFLSAKI 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	12/36 (33%)
		PDZ_signaling	163..244	CDD:238492	56/80 (70%)
		PHsplit_syntrophin	<293..351	CDD:269960	22/57 (39%)
sntb1	NP_001002175.1	PDZ_signaling	89..170	CDD:238492	56/80 (70%)
		PHsplit_syntrophin	<220..277	CDD:269960	22/56 (39%)
		PH	301..410	CDD:278594	36/149 (24%)
		PH	301..410	CDD:214574	36/149 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576811
Domainoid	1	1.000	116	1.000	Domainoid score	I5909
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9618
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2290
OMA	1	1.010	-	-		QHG45230
OrthoDB	1	1.010	-	-		D1261897at2759
OrthoFinder	1	1.000	-	-		FOG0003604
OrthoInspector	1	1.000	-	-		otm25219
orthoMCL	1	0.900	-	-		OOG6_108779
Panther	1	1.100	-	-	LDO	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2806
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900