DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Syn1 and GRID2IP

DIOPT Version :9

Sequence 1:NP_001262192.1 Gene:Syn1 / 40424 FlyBaseID:FBgn0037130 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_001138590.1 Gene:GRID2IP / 392862 HGNCID:18464 Length:1211 Species:Homo sapiens


Alignment Length:398 Identity:84/398 - (21%)
Similarity:127/398 - (31%) Gaps:160/398 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 AGDGGGMDMCDVPDHVANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLY 207
            ||.||.             :|.||:.|. |...|.:::|    ..|:.|..:..|..||.| .|.
Human   271 AGPGGA-------------RRTVRVYKG-NKSFGFTLRG----HGPVWIESVLPGSPADNA-ALK 316

  Fly   208 VGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEV--------------------------KFL 246
            .||.||.:||.::|:.:||:.|..|:.||.:..|.|                          :::
Human   317 SGDRILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWV 381

  Fly   247 REVTP--------------------------------YFRKASI--------------ISEVGWE 265
            .|:.|                                :|:..:|              ..:|.|:
Human   382 AEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQHRNIDTLIVDVYPVLDTPAKQVLWQ 446

  Fly   266 L-------------QRAFLCPLGPGVPT----------SPPAPKTTPRADTRYIPLQLTHLARNL 307
            .             |....|.||....|          |.|.|:..||:..|...:    ..|:|
Human   447 FIYQLLTYEEQELCQEKIACFLGYTAMTAEPEPELDLESEPTPEPQPRSSLRASSM----CRRSL 507

  Fly   308 KYIDPE-------NRCFELHSP---------DGVH-----SCILRAADSAEALVWFN-ALHSAMG 350
            :....|       :.|.|:..|         ||..     :..:.:|..||.....| :....||
Human   508 RSQGLEAGLSCGPSECPEMPLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMG 572

  Fly   351 T-STQRALAEA-NRALTNLIGELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGELVSP 413
            | |..||.... :.|:|.....|..:.|.|:|:.               .|...:.:.:|.|.||
Human   573 TVSKSRASPPGPSPAVTTGPRTLSGVSWPSERLL---------------PSPCYHPLCSGGLASP 622

  Fly   414 SGRSSSES 421
               |||||
Human   623 ---SSSES 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syn1NP_001262192.1 PH-like 30..>61 CDD:302622
PDZ_signaling 163..244 CDD:238492 29/106 (27%)
PHsplit_syntrophin <293..351 CDD:269960 14/79 (18%)
GRID2IPNP_001138590.1 PDZ_signaling 14..74 CDD:238492
HN_L-delphilin-R1_like 133..212 CDD:259820
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..269
PDZ_signaling 278..353 CDD:238492 28/80 (35%)
HN_L-delphilin-R2_like 389..468 CDD:259821 6/78 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..502 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 525..549 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..600 9/31 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..672 8/13 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..783
FH2 820..1188 CDD:280362
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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