DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and inaD

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	335	Identity:	74/335 - (22%)
Similarity:	115/335 - (34%)	Gaps:	117/335 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SPSGLRCGNMET----------RVRGAWYRVLVTL--ETDF---LAVSLDESCEAAQPSNDGQST 74
            ||:.| ||.::.          .||.:..:.::.|  |.||   |.:...:..:..|..:|.:|
  Fly    69 SPAHL-CGRLKVGDRILSLNGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRS- 131

  Fly    75 TLNG------------TLGSNHSGGGGGGAG-GGGTGGGGQNGTLPNSASLQGMNI--------- 117
              ||            |..:|.|||.|.|.| |.|.|..|.|    ...|:|..|.
  Fly   132 --NGYMQAKNKFNQEQTTNNNASGGQGMGQGQGQGQGMAGMN----RQQSMQKRNTTFTASMRQK 190

  Fly   118 ---------QDT-------------ELD-GSASN-----DNGDRDPCLNNNNNAGDGGGMDMCDV 154
                     :||             |:| .||.|     ...|||      ....|..|..|..:
  Fly   191 HSNYADEDDEDTRDMTGRIRTEAGYEIDRASAGNCKLNKQEKDRD------KEQEDEFGYTMAKI 249

  Fly   155 PDHVANQK--RHVRIIKSDNNGLGISIKGGRE-NRMPILISKIFRGMAADQAKG---LYVGDAIL 213
            .......|  |.:.:.:..:..||:::.|.:: .:|...::    |:..:.|.|   :..||.|:
  Fly   250 NKRYNMMKDLRRIEVQRDASKPLGLALAGHKDRQKMACFVA----GVDPNGALGSVDIKPGDEIV 310

  Fly   214 TVNGEELRDATH-------------------------DE--AVRALKRSGRVVDLEVKFLREVTP 251
            .|||..|::..|                         ||  .|:.:|:.....| |.||:.:..|
  Fly   311 EVNGNVLKNRCHLNASAVFKNVDGDKLVMITSRRKPNDEGMCVKPIKKFPTASD-ETKFIFDQFP 374

  Fly   252 YFRKASIISE 261
            ..|...:..|
  Fly   375 KARTVQVRKE 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	9/45 (20%)
		PDZ_signaling	163..244	CDD:238492	22/111 (20%)
		PHsplit_syntrophin	<293..351	CDD:269960
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	12/46 (26%)
		PDZ_signaling	259..340	CDD:238492	16/84 (19%)
		PDZ_signaling	377..457	CDD:238492	2/8 (25%)
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900