DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn1 and Syn2

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_788381.1	Gene:	Syn2 / 36848	FlyBaseID:	FBgn0034135	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	122/497 - (24%)
Similarity:	217/497 - (43%)	Gaps:	92/497 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 NQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDAT 224
            :::|.|:|.:....|||:|||||.|:::|||||:|::..|||....|:|||||:.||||.:....
  Fly    74 SKERMVQITRQKQGGLGLSIKGGAEHKLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACP 138

  Fly   225 HDEAVRALKRSGRVVDLEVKFLREVTPYFRK---------------ASIISEVGWE-------LQ 267
            ||:||..|:.:|.:|.|.||..|..||:.:|               |.:.::.|::       :.
  Fly   139 HDDAVNILRNAGDIVVLTVKHYRAATPFLQKQLTKDTPDSDNDVTCAELKADEGYKSSVNSGTIS 203

  Fly   268 RAFLCPLGPGVPTSPPAPKTTPRADTRYIPLQLTHLARNLKYIDP-ENRCFELHSPDGVHSCILR 331
            |:...|:.   ..|.|..:.|   |...:||.:.::.|.:...|. ....||:...:|:.:.::.
  Fly   204 RSCSRPMS---ICSEPEKRWT---DVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIH 262

  Fly   332 AADSAEALVWFNAL-HSAMG-TSTQRALAEANRALTNLIGE-LKHIGWLSKRMSGGGSSGSAGGG 393
            ..:.|....|...: .:.:| |..|..|...|.|    :|| ::::||:::
  Fly   263 CDELAILSQWLKLITDNVVGLTHLQMKLYNRNFA----VGERIEYMGWVNE-------------- 309

  Fly   394 AASGGSGTSNSVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLE 458
                  |..|:.::.:                 .:.|.|:.:...|..::|:.|.:|...|:.|.
  Fly   310 ------GVINNNISWQ-----------------SYKPRFLLLKGTEVMLFETPPLNVAGISKALV 351

  Fly   459 IYALATTRLAGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVN 523
            :|.:..|.......:.:::.:|........|.....|....|.|..|...:|..::|.   ..:.
  Fly   352 VYKVYQTMFRIVKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIENSWNAAIVT---SVIK 413

  Fly   524 YQREFSFRCLFQGRQCQLVVHINRGFFLYDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGAR 588
            ..|: :|.....|:...|.:....||.|           |.......:||:.|.:|:||:|||..
  Fly   414 LGRK-TFAVSHHGKSGGLTLDWQAGFSL-----------TEGAESATVWQYKFSQLRGSSDDGKS 466

  Fly   589 MLYLDFGEDGE--IEL-DMEC-CPKPVVFVVHNCLSAKVHNI 626
            .|.|.|.:...  ||. ::|| ..:.::|.:|..|:|||.::
  Fly   467 KLKLHFQDHDSRAIETKELECQVLQSLLFCMHAFLTAKVASV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	39/80 (49%)
		PHsplit_syntrophin	<293..351	CDD:269960	10/60 (17%)
Syn2	NP_788381.1	PDZ_signaling	76..158	CDD:238492	39/81 (48%)
Syn2	NP_788381.1	PH	301..407	CDD:214574	21/142 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39697at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10554
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950