Protein Alignment Syn1 and stn-1

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_492521.1
• Gene: stn-1 / 266844
• WormBaseID: WBGene00006062
• Length: 440
• Species: Caenorhabditis elegans
• Alignment Length: 604
• Identity: 181/604 - (29%)
• Similarity: 273/604 - (45%)
• Gaps: 173/604 - (28%)

  Fly    27 SGLRCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGG 91
            :.:|.|.::..|:|.|:|||.||:
 Worm     2 AAVRSGLVDIFVQGQWHRVLATLD----------------------------------------- 25

  Fly    92 AGGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPD 156
                           |.:.:||.|...:.|.
 Worm    26 ---------------PTAITLQTMEQNEAEA---------------------------------- 41

  Fly   157 HVANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELR 221
                :||.||::|.|.|||||||||||:|.|||:|||||:|||||||..|::.|.|::||||.|.
 Worm    42 ----EKRTVRVVKYDGNGLGISIKGGRDNNMPIVISKIFKGMAADQAGELFLDDVIISVNGENLL 102

  Fly   222 DATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPAPK 286
            ||:|:||||||||:||||||:|::.||  ....:.:|:..|.|:
 Worm   103 DASHEEAVRALKRAGRVVDLQVQYRRE--DMMHRENIVENVEWD--------------------- 144

  Fly   287 TTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALHSAMGT 351
            ...|...|.|.|:|.::||.....|.|.|..|:.||.|.:|..:|.:.|.||..||.|||:....
 Worm   145 DDIRERVRTIGLKLAYVARAGIDADAEGRILEMRSPSGRYSLAMRCSSSEEADGWFEALHACTTC 209

  Fly   352 STQRALAEANRALTNLIGELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGELVSPSGR 416
            ...:|||:.|..|.| ..:::|:||:::::|..|.|
 Worm   210 LLTQALAQVNIMLGN-NPQVRHMGWIAEQVSENGIS----------------------------- 244

  Fly   417 SSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRLAGAGNNSS--LNGQ 479
                      .|.|.|:.:|..|...||:.|.....|:.|..:..|..||:....:.::  :.|.
 Worm   245 ----------MWKPKFMTLTNSEILFYEAVPQLKAEWAEPRLVRPLVATRVVQTSSRTAPVIKGL 299

  Fly   480 QTTV-FCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFRCLFQGRQCQLVV 543
            ...: |.:|.||.:||..:.:|.|||.::|.|.|::|.|.::|.....:.|..||::|..|:|:|
 Worm   300 TDVISFRMRTGTQQGVRTHTIRVETHAELARWVRAVVIGGYEACLSTSQVSAPCLWRGESCELIV 364

  Fly   544 HINRGFFLYDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDFG-EDGEIELDMECC 607
            :::.|..|....|            ..|||.:|:.::.:.|||.|.|::||| ..||.|||:...
 Worm   365 NLDNGISLLSSTG------------EVLWQHSFETIRATGDDGGRFLWVDFGPPHGEQELDLLNS 417

  Fly   608 PKPVVFVVHNCLSAKVHNI 626
            .|||||::|:.|:.||:.:
 Worm   418 AKPVVFILHSFLATKVYRL 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	10/30 (33%)
		PDZ_signaling	163..244	CDD:238492	57/80 (71%)
		PHsplit_syntrophin	<293..351	CDD:269960	23/57 (40%)
stn-1	NP_492521.1	PDZ_signaling	44..125	CDD:238492	57/80 (71%)
		PH-like	<152..208	CDD:302622	23/55 (42%)
		PH	228..334	CDD:278594	32/144 (22%)
		PH	228..334	CDD:214574	32/144 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157900
Domainoid	1	1.000	117	1.000	Domainoid score	I3715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9618
Inparanoid	1	1.050	270	1.000	Inparanoid score	I1832
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45230
OrthoDB	1	1.010	-	-		D1261897at2759
OrthoFinder	1	1.000	-	-		FOG0003604
OrthoInspector	1	1.000	-	-		oto18386
orthoMCL	1	0.900	-	-		OOG6_108779
Panther	1	1.100	-	-	LDO	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2806
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940