Protein Alignment Syn1 and WHRN

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: XP_011516787.1
• Gene: WHRN / 25861
• HGNCID: 16361
• Length: 918
• Species: Homo sapiens
• Alignment Length: 666
• Identity: 141/666 - (21%)
• Similarity: 219/666 - (32%)
• Gaps: 252/666 - (37%)

  Fly    73 STTLNGTLGSNHSGGGGGGAGGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDP-- 135
            |::..|:|||....|||||||                ..|...|::......:|.....:|:.
Human    11 SSSSTGSLGSAAGAGGGGGAG----------------LRLLSANVRQLHQALTALLSEAEREQFT 59

  Fly   136 -CLN---NNNNAGD--------------------------------------------------- 145
             |||   ...|..|
Human    60 HCLNAYHARRNVFDLVRTLRVLLDSPVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYRQ 124

  Fly   146 ---GGGMDMCDVPDHVANQKRHVRIIK----SDNNGLGISIKGGRENRMPILISKIFRGMAADQA 203
               ||       ||...  ...||::.    ..:.|||.||:||.|:.:.|.:|.:..|..|::
Human   125 PAWGG-------PDSAG--PGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEK- 179

  Fly   204 KGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQR 268
            :||.|||.||.||.:.|...||.|||:|||.|.::|                .|:.|
Human   180 EGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLV----------------LSVYS-------- 220

  Fly   269 AFLCPLGPGVPTSPPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGV---HSCIL 330
            |...|.|                   |:   ..|:   ..::||:.|  .:..|.|:   |...|
Human   221 AGRIPGG-------------------YV---TNHI---YTWVDPQGR--SISPPSGLPQPHGGAL 258

  Fly   331 RAADSAEALVWFNALHSAMGTSTQRALAEANRALTNLI-GELKHIGWLSKRMSGGGSSG------ 388
            |..:....    :.||...|...::         .||: |:.:.:| |:.|  ||...|
Human   259 RQQEGDRR----STLHLLQGGDEKK---------VNLVLGDGRSLG-LTIR--GGAEYGLGIYIT 307

  Fly   389 SAGGGAASGGSGTSNSVVAGELVSPSGRS-SSESSDESDKWLPI--FVAVTEREFRIYESAPWSV 450
            ....|:.:.|||..   |..:::..:||| .:...||:.:.|..  .:.:|.::......|..:|
Human   308 GVDPGSEAEGSGLK---VGDQILEVNGRSFLNILHDEAVRLLKSSRHLILTVKDVGRLPHARTTV 369

  Fly   451 E-----AWSRPLEIYA--------LATTRLAGAGNNSSLNGQQTTVFCVRCGTARGVLV-----Y 497
            :     |.||..|..|        |.|..:...|......|.|.|:..:  |....||:     :
Human   370 DETKWIASSRIRETMANSAGFLGDLTTEGINKPGFYKGPAGSQVTLSSL--GNQTRVLLEEQARH 432

  Fly   498 WLRSETHRDMAAW----------ARSLVQGSHQAVNYQREFSFRCLFQG---------------- 536
            .|..:.|..||.:          ..:||....:.:|...:||.....:|
Human   433 LLNEQEHATMAYYLDEYRGGSVSVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLR 497

  Fly   537 --------RQ---------CQLVVHINRGFFLYDCGGFAPTTPTVATAKTQ-LWQFAFDKLKGSA 583
                    ||         ..:|.:.:.|    ...|...|:.||::|:.: ||  ..|.::.:
Human   498 REIESMKARQPPGPGAGDTYSMVSYSDTG----SSTGSHGTSTTVSSARERLLW--LIDLMENT- 555

  Fly   584 DDGARMLYLDFGEDGE 599
                    ||..|.||
Human   556 --------LDLEETGE 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	34/84 (40%)
		PHsplit_syntrophin	<293..351	CDD:269960	12/60 (20%)
WHRN	XP_011516787.1	HN_L-whirlin_R1_like	37..112	CDD:259822	8/74 (11%)
		PDZ_signaling	138..215	CDD:238492	33/77 (43%)
		PDZ_signaling	277..357	CDD:238492	21/94 (22%)
		HN_L-whirlin_R2_like	419..499	CDD:259823	13/79 (16%)
		PDZ_signaling	827..898	CDD:238492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810