DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Syn1 and GRIP1

DIOPT Version :9

Sequence 1:NP_001262192.1 Gene:Syn1 / 40424 FlyBaseID:FBgn0037130 Length:627 Species:Drosophila melanogaster
Sequence 2:XP_016874587.1 Gene:GRIP1 / 23426 HGNCID:18708 Length:1188 Species:Homo sapiens


Alignment Length:544 Identity:109/544 - (20%)
Similarity:177/544 - (32%) Gaps:215/544 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 VTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGGGGTGGGGQNGTLPNSAS 111
            ||||.:|      :..|:..||    |.|.:..|...|:...|              .|:.:.:|
Human   628 VTLEIEF------DVAESVIPS----SGTFHVKLPKKHNVELG--------------ITISSPSS 668

  Fly   112 LQ---GMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVANQKR-----HVRII 168
            .:   .:.|.|.: .||.::..|..:  |.:...|.|...:|.|.:.|.|...::     .::|.
Human   669 RKPGDPLVISDIK-KGSVAHRTGTLE--LGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIR 730

  Fly   169 KSDNNG---------------------LGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAI 212
            |.::|.                     |||:|.|..|...||:||.:.:|..|::...:::||.|
Human   731 KDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRI 795

  Fly   213 LTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREV----TPYFRKASIISEVGWELQRAFLCP 273
            |.:|...|:.....||:..|:.:|..|.|::|...:.    :|  :|..|.|.         |..
Human   796 LAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSP--KKFPISSH---------LSD 849

  Fly   274 LGPGVPTSPPA----------PKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSC 328
            ||.....|.||          |.|.|..|:                        .:.|.||    
Human   850 LGDVEEDSSPAQKPGKLSDMYPSTVPSVDS------------------------AVDSWDG---- 886

  Fly   329 ILRAADSAEALVWFNALHSAMGTSTQRALAEANRALTNLIGELKHIGWLSKRMSGGGSSGSAGGG 393
              .|.|::         :...|||.|.:....|.           ..|.|.:..|.         
Human   887 --SAIDTS---------YGTQGTSFQASGYNFNT-----------YDWRSPKQRGS--------- 920

  Fly   394 AASGGSGTSNSVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLE 458
                             :||                     ||:...:.|.....|.|.|.|   
Human   921 -----------------LSP---------------------VTKPRSQTYPDVGLSYEDWDR--- 944

  Fly   459 IYALATTRLAGAGNNSSLNGQQTTVFCVR-------CGTARGVLVYWLRSETHRDMAAWARSLVQ 516
                 :|....||...|...:|...|..:       ||.: |:|         |::.|   :::.
Human   945 -----STASGFAGAADSAETEQEENFWSQALEDLETCGQS-GIL---------RELEA---TIMS 991

  Fly   517 GSHQAVNYQ---------REFSFR 531
            ||..::|::         |:.||:
Human   992 GSTMSLNHEAPTPRSQLGRQASFQ 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syn1NP_001262192.1 PH-like 30..>61 CDD:302622 5/13 (38%)
PDZ_signaling 163..244 CDD:238492 27/106 (25%)
PHsplit_syntrophin <293..351 CDD:269960 5/57 (9%)
GRIP1XP_016874587.1 PDZ_signaling 128..208 CDD:238492
PDZ_signaling 227..310 CDD:238492
PDZ_signaling 325..408 CDD:238492
PDZ_signaling 545..633 CDD:238492 4/4 (100%)
PDZ_signaling 646..730 CDD:238492 18/100 (18%)
PDZ_signaling 746..827 CDD:238492 24/80 (30%)
PDZ_signaling 1062..1142 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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