Protein Alignment Syn1 and Sntb2

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_001355245.1
• Gene: Sntb2 / 20650
• MGIID: 101771
• Length: 531
• Species: Mus musculus
• Alignment Length: 536
• Identity: 186/536 - (34%)
• Similarity: 260/536 - (48%)
• Gaps: 118/536 - (22%)

  Fly    30 RCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGG 94
            :.|.:|..:|..|.||:..|..:.|:::.|.:....:|    .:...||.
Mouse     9 KAGLVELLLRERWVRVVAELSGESLSLTGDAAAVEPEP----PAAAFNGL--------------- 54

  Fly    95 GGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVA 159
             ..||||::                  |.||.:...|...|.......||:..          .:
Mouse    55 -PNGGGGES------------------LPGSPNRGLGPPSPPAPPRGPAGEAS----------AS 90

  Fly   160 NQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDAT 224
            ...|.||::|.:..||||||||||||||||||||||.|:||||::.|.:|||||:|||.:||.||
Mouse    91 PPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQAT 155

  Fly   225 HDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPT--------S 281
            ||:||:||||:|:.|.|||||:||||||.:|.|::|::.||       ...|..|:        |
Mouse   156 HDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWE-------GASPQSPSFSGSEDSGS 213

  Fly   282 PPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALH 346
            |....||  .|.:.|||::...||||...|.|||..||||||..::.|||..|:|.|..||.|:|
Mouse   214 PKHQNTT--KDRKVIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIH 276

  Fly   347 SAMGTSTQRALAEANRAL--TNLIG---ELKHIGWLSK--RMSGGGSSGSAGGGAASGGSGTSNS 404
            :.:.....:.|||.|..|  |:..|   |:|||.||::  ::.||
Mouse   277 TNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGG-------------------- 321

  Fly   405 VVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRL-- 467
                                ..:|.|:.:||||::..:|:..||:.:||:.|...|.|..|||
Mouse   322 --------------------RQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVH 366

  Fly   468 AGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSF-- 530
            :|:|..|...|...| |..|.|:.:|:.::..|.|||||::.|.|.||||.|.|....:|.|.
Mouse   367 SGSGCRSPSLGSDLT-FATRTGSRQGIEMHLFRVETHRDLSTWTRILVQGCHAAAELIKEVSLDY 430

  Fly   531 -RCLFQGRQCQLVVHI 545
             ........|..:.|:
Mouse   431 GPAFLSKADCICIAHV 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	9/30 (30%)
		PDZ_signaling	163..244	CDD:238492	56/80 (70%)
		PHsplit_syntrophin	<293..351	CDD:269960	27/57 (47%)
Sntb2	NP_001355245.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..95		14/97 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..220		6/31 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834110
Domainoid	1	1.000	160	1.000	Domainoid score	I4056
eggNOG	1	0.900	-	-		E1_KOG3551
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2047
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45230
OrthoDB	1	1.010	-	-		D1261897at2759
OrthoFinder	1	1.000	-	-		FOG0003604
OrthoInspector	1	1.000	-	-		otm43072
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2806
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.900