DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syn1 and Snta1

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_033254.2	Gene:	Snta1 / 20648	MGIID:	101772	Length:	499	Species:	Mus musculus

Alignment Length:	608	Identity:	207/608 - (34%)
Similarity:	296/608 - (48%)	Gaps:	143/608 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LRCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAG 93
            ||||.........|.|||::|..|.|.||         |::
Mouse    15 LRCGAGSGAGGERWQRVLLSLAEDALTVS---------PAD------------------------ 46

  Fly    94 GGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHV 158
                   |:.|..|..|.|                 ||..:|            |.....:|:.:
Mouse    47 -------GEPGPEPEPAQL-----------------NGAAEP------------GAAPPQLPEAL 75

  Fly   159 ANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDA 223
            ..|:|.|.:.|:|..||||||||||||:|||||||||:|:||||.:.|:||||||:||||:|..|
Mouse    76 LLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSA 140

  Fly   224 THDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWE------LQRAFLCPLGPGVPTSP 282
            ||||||:|||::|:.|.||||:::||:|||:.::..:.|||:      |||.         |:||
Mouse   141 THDEAVQALKKTGKEVVLEVKYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQ---------PSSP 196

  Fly   283 -PAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALH 346
             |.|:..  ::.:::.|::.:::|.....|||.|..|:.:.||..:..|||.|.|.|..|..|:.
Mouse   197 GPQPRNL--SEAKHVSLKMAYVSRRCTPTDPEPRYLEICAADGQDAVFLRAKDEASARSWAGAIQ 259

  Fly   347 SAMGTSTQRALAEANRAL--TNLIG--ELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVA 407
            :.:||.......|....|  |...|  ::|.||||::::..||::
Mouse   260 AQIGTFIPWVKDELQALLTATGTAGSQDIKQIGWLTEQLPSGGTA-------------------- 304

  Fly   408 GELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRLAGAG- 471
                                  |....:||:|...|.|.|.|.||.|||.....|..|||..:|
Mouse   305 ----------------------PTLALLTEKELLFYCSLPQSREALSRPTRTAPLIATRLVHSGP 347

  Fly   472 NNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFRCLFQG 536
            :..|:.......|.:|.||..||..:....|:.:::|||.|.||.|.|:|....:|.|..|.:.|
Mouse   348 SKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGIQEVSTACTWNG 412

  Fly   537 RQCQLVVHINRGFFLYDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDF-GEDGEI 600
            |.|.|.|||::||.|:        ......|:..|.:..|:||:.|:|||..:|:||| |.:|||
Mouse   413 RPCSLSVHIDKGFTLW--------AAEPGAARAMLLRQPFEKLQMSSDDGTSLLFLDFGGAEGEI 469

  Fly   601 ELDMECCPKPVVFVVHNCLSAKV 623
            :||:..|||.:||::|:.|||||
Mouse   470 QLDLHSCPKTMVFIIHSFLSAKV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	12/30 (40%)
		PDZ_signaling	163..244	CDD:238492	56/80 (70%)
		PHsplit_syntrophin	<293..351	CDD:269960	17/57 (30%)
Snta1	NP_033254.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..68		13/96 (14%)
		PDZ_signaling	80..161	CDD:238492	56/80 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	177..203		11/34 (32%)
		PHsplit_syntrophin	<203..264	CDD:269960	17/62 (27%)
		PH	292..395	CDD:278594	38/144 (26%)
		PH	292..395	CDD:214574	38/144 (26%)
		Calmodulin-binding	477..499		10/16 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834111
Domainoid	1	1.000	117	1.000	Domainoid score	I5882
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2047
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45230
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43072
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10554
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.000