DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Syn1 and Mpdz

DIOPT Version :9

Sequence 1:NP_001262192.1 Gene:Syn1 / 40424 FlyBaseID:FBgn0037130 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_001292213.1 Gene:Mpdz / 17475 MGIID:1343489 Length:2069 Species:Mus musculus


Alignment Length:652 Identity:151/652 - (23%)
Similarity:230/652 - (35%) Gaps:191/652 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 TPPAAQQ------PIPQQHSPSPSGLRCGNMETRVRGAWYRVLV---TLETDFLAVSL----DES 61
            |..|.:|      |:...||..||.|....:...:.....:.|.   :|.:|..:|:|    .|:
Mouse   928 TTNAVEQKYECANPVAWPHSQLPSSLSTSELAPALPAVAQKYLTDQSSLASDAESVNLQSMSQEA 992

  Fly    62 CEAAQPSNDGQSTTLNGTLGSNHSGGG--------GGGAGGGGTGGGG-------QNGT--LPNS 109
            .|.......| |::|..|:.:|..|.|        ||.....|....|       :..|  |.|:
Mouse   993 FERTVTIAKG-SSSLGMTVSANKDGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLTNA 1056

  Fly   110 ---ASLQGMNIQDTELDGSASNDNGDRDPC---------------LNNNNNAG---------DGG 147
               |.|:..::...::..||:..: ||.|.               ::....||         ...
Mouse  1057 QARAMLRRHSLIGPDIKFSAAPAD-DRAPFYVITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYT 1120

  Fly   148 GMDMCDVPDHVA----------------NQKRHVRIIKSDNNGLGISIKGGR---------ENRM 187
            |.|:.::|:...                :|.|.|.:.:..:..|||||.|||         |...
Mouse  1121 GRDIPELPEREEGEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMR 1185

  Fly   188 PILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPY 252
            .|.|..:.....|.:...|..||.|:.|:|.:||||:|::||.|::::|..|            .
Mouse  1186 GIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDLRDASHEQAVEAIRKAGNPV------------V 1238

  Fly   253 FRKASIISEVGWELQRAFLCPLGPGVPTSPPAPK-----TTPRADTRYIPLQLTHLARNLKYID- 311
            |...|||:       |....|| |.:|.| ..||     |.|.||:    ||||        .| 
Mouse  1239 FMVQSIIN-------RPRKSPL-PSLPHS-LYPKYSFSSTNPFADS----LQLT--------TDQ 1282

  Fly   312 -PENRCFELHSPDGVHSCILRAADSAEALVWFNALHSAMGTSTQRALAE--------------AN 361
             |.....|...|     .:.....|:.::  |:.:.|.....:..|::|              ..
Mouse  1283 APSQSESETEKP-----ALCNVPPSSPSV--FSEMGSDCAQPSATAVSEDEDKEDEFGYSWKNIQ 1340

  Fly   362 RALTNLIGELKHIGWLSKRMSGGGSSGSAG------------GGAASGGSGTSNSV-VAGELVSP 413
            ....:|.|:| |:..|.|..||.|.| .||            |...:|.:|....: :|.||:..
Mouse  1341 ERYGSLTGQL-HVIELEKGQSGLGLS-LAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEI 1403

  Fly   414 SGR----SSSESSDESDKWLP-----IFV----AVTEREF--RIYESAPWSVEAWSRPLEIYALA 463
            :|:    .|.:::....|..|     ||:    ||.:...  .|...:|.|.....:..|:...:
Mouse  1404 NGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGIAADSPSSTSDSPQNKEVEPCS 1468

  Fly   464 TTRLAGAGNNSSL-----------NGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQG 517
            ||. |.|.:.|||           .|......|.. .|..||::   .|.|....||....|..|
Mouse  1469 TTS-ASAADLSSLTDVYQLELPKDQGGLGIAICEE-DTINGVMI---ESLTEHGGAAKDGRLKPG 1528

  Fly   518 SH 519
            .|
Mouse  1529 DH 1530

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syn1NP_001262192.1 PH-like 30..>61 CDD:302622 5/37 (14%)
PDZ_signaling 163..244 CDD:238492 30/89 (34%)
PHsplit_syntrophin <293..351 CDD:269960 11/59 (19%)
MpdzNP_001292213.1 L27_2 6..63 CDD:117611
PDZ_signaling 140..222 CDD:238492
PDZ_signaling 256..335 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..372
PDZ 375..464 CDD:214570
PDZ_signaling 553..622 CDD:238492
PDZ_signaling 694..777 CDD:238492
PDZ_signaling 994..1064 CDD:238492 17/70 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1125..1144 1/18 (6%)
PDZ_signaling 1151..1242 CDD:238492 31/102 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1313 8/49 (16%)
PDZ 1349..1434 CDD:214570 22/86 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1449..1473 5/24 (21%)
PDZ_signaling 1483..1563 CDD:238492 12/52 (23%)
MPDZ_u10 1564..1625 CDD:293272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1571..1611
PDZ 1626..1710 CDD:214570
PDZ_signaling 1722..1802 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1809..1848
PDZ_signaling 1859..1944 CDD:238492
PDZ_signaling 1985..2068 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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