DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and TAMALIN

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_859062.1	Gene:	TAMALIN / 160622	HGNCID:	18707	Length:	395	Species:	Homo sapiens

Alignment Length:	303	Identity:	68/303 - (22%)
Similarity:	104/303 - (34%)	Gaps:	79/303 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GGGMDMCDVPDHVANQKRHVRIIKSDNNGLGISIKG-GRENR------MPILISKIFRGMAADQA 203
            |.|....::......|::.:.:.|.||...|..|:. |..:|      |...:.::.....| |.
Human    83 GSGFRWKNLSQSPEQQRKVLTLEKEDNQTFGFEIQTYGLHHREEQRVEMVTFVCRVHESSPA-QL 146

  Fly   204 KGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQR 268
            .||..||.|.:|||..:....|.|.|..:|.||.|:.||..:...:    |||.:.:.:.:..|.
Human   147 AGLTPGDTIASVNGLNVEGIRHREIVDIIKASGNVLRLETLYGTSI----RKAELEARLQYLKQT 207

  Fly   269 AFLCPLGPGVPTSPPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAA 333
            .:                 ....:.|.:.:|...|...|...||.    ...:.:.|.||:..|.
Human   208 LY-----------------EKWGEYRSLMVQEQRLVHGLVVKDPS----IYDTLESVRSCLYGAG 251

  Fly   334 DSAEALVWFNALHSAMGT---STQRALAEANRAL--TNLIG----------------------EL 371
            ....:|. |..|.:..|.   ..:||..:|:.|:  |...|                      |.
Human   252 LLPGSLP-FGPLLAVPGRPRGGARRARGDADDAVYHTCFFGDSEPPALPPPPPPARAFGPGPAET 315

  Fly   372 KHIG-------WLSKRMS------GGGSSGSAGGGAASGGSGT 401
            ..:|       .||:..|      |||     |||.|.|...|
Human   316 PAVGPGPGPRAALSRSASVRCAGPGGG-----GGGGAPGALWT 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	27/87 (31%)
		PHsplit_syntrophin	<293..351	CDD:269960	13/57 (23%)
TAMALIN	NP_859062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PDZ_signaling	100..185	CDD:238492	25/85 (29%)
		Interaction with PSCD3. /evidence=ECO:0000250	181..258		17/101 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..349		12/60 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900