DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and Lnx2

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_542985.4	Gene:	Lnx2 / 140887	MGIID:	2155959	Length:	687	Species:	Mus musculus

Alignment Length:	188	Identity:	46/188 - (24%)
Similarity:	78/188 - (41%)	Gaps:	39/188 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GGGGQNGTLPNSASLQGMNIQD-----TELDGSASNDNGDR-----------DPCLNNNNNAGDG 146
            |...|:|.|.::..:..:|..|     .||.......:|:|           .|. |.:..||..
Mouse   372 GLAAQDGRLNSNDRVLAINGHDLKHGTPELAAQIIQASGERVNLTIARPGKPQPS-NGSREAGAH 435

  Fly   147 GGMDMCDVPDH------------VANQKRHVRIIKSDNNGLGISIKGGRENR---MPILISKI-F 195
            ...:....|.|            |..|::|:.:.|..:..||:::.|||.::   :||.::.: .
Mouse   436 SSSNHAQPPSHSRPGSHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPP 500

  Fly   196 RGMAADQAKGLYVGDAILTVNGEELRDATHDEAVRALKRSGR-----VVDLEVKFLRE 248
            .|..|...: :..||.:|.:||.:|.:.:|.|||..||.|..     :..|||:...|
Mouse   501 HGCLARDGR-IKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVILKALEVQIAEE 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	26/89 (29%)
		PHsplit_syntrophin	<293..351	CDD:269960
Lnx2	NP_542985.4	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..175
		NPXY motif	207..210
		PDZ	229..315	CDD:214570
		PDZ_signaling	336..418	CDD:238492	10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..454		6/37 (16%)
		PDZ_signaling	463..539	CDD:238492	23/76 (30%)
		PDZ_signaling	596..680	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900