DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and cytip

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_003199223.2	Gene:	cytip / 100537036	ZFINID:	ZDB-GENE-140106-76	Length:	343	Species:	Danio rerio

Alignment Length:	337	Identity:	72/337 - (21%)
Similarity:	126/337 - (37%)	Gaps:	87/337 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 NSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHVANQKRHVRIIKSDN 172
            |:..::|..:..::|..:.||                        .:.|:...|:..|.:.|.||
Zfish    46 NTEGMKGRTLSQSQLARTHSN------------------------SLVDYTDPQRTMVVLEKQDN 86

  Fly   173 -------NGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHDEAVR 230
                   ...|:.:|......|...:.::..|.||:.| ||..||.||:|||..:..:||...:.
Zfish    87 EVFGFEVQTYGLKVKNTSMVEMCTFVCRVQDGSAAETA-GLTAGDIILSVNGVSIEGSTHQNIIE 150

  Fly   231 ALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPAPKTTPRADTRY 295
            .::.|...:.||..          ..|::..:..|.:..:|              |.|.|  .::
Zfish   151 LIRESSNTLKLETV----------SGSVMKRIELEKKMHYL--------------KQTLR--EKW 189

  Fly   296 IPLQ--------LT--HLARNLKYIDPENRCFELHSPDG--------VHSCILRAADSAEALVWF 342
            :.||        ||  :|..:.:|:..:: ...|.||.|        ..||.....|.:|...:
Zfish   190 VELQSLTLKEKRLTQGNLNESAQYLSVDS-VMSLSSPMGRSGQRFSSDSSCRSIMTDDSEDGAF- 252

  Fly   343 NALHSAMGTSTQRALAEANRALTNL-IGELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVV 406
              :.|....|:..:..|::.:...| :|.|:.| ..::.:|..||:.|     .|.|..||.|.:
Zfish   253 --MSSVFDDSSPLSPIESSGSFFQLEVGALRPI-TRTRSISLTGSNSS-----LSPGWETSPSSL 309

  Fly   407 AGELVSPSGRSS 418
            .|.|...|.:.|
Zfish   310 FGTLPRRSRKGS 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	25/87 (29%)
		PHsplit_syntrophin	<293..351	CDD:269960	15/75 (20%)
cytip	XP_003199223.2	PDZ_signaling	78..162	CDD:238492	23/84 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900