Protein Alignment Syn1 and sntb1

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: XP_012820630.1
• Gene: sntb1 / 100493340
• XenbaseID: XB-GENE-1013041
• Length: 509
• Species: Xenopus tropicalis
• Alignment Length: 605
• Identity: 230/605 - (38%)
• Similarity: 331/605 - (54%)
• Gaps: 121/605 - (20%)

  Fly    29 LRCGNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAG 93
            ||.|.:|..|||.|::||..|....|.:|..|..|.|..||    :..|||
 Frog     9 LRSGWLEVLVRGRWHKVLGNLYESSLVLSSPERPEDAPSSN----SMTNGT-------------- 55

  Fly    94 GGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNNNNNAGDGGGMDMCDVPDHV 158
                           ::|.||:....|||..:                            ||:.:
 Frog    56 ---------------NSSPQGVRTAFTELPDT----------------------------VPEAI 77

  Fly   159 ANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDA 223
            ||:||.|:::|.:..|||||||||:||:|||||||||:|:||||.:.||||||||||||.:||||
 Frog    78 ANKKRAVKVVKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQSLYVGDAILTVNGLDLRDA 142

  Fly   224 THDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWELQRAFLCPLGPGVPTSPPAP-KT 287
            ||||||:|||::||.|.||||::||.|||.:|.|.:||:|||........|| .....||:| ..
 Frog   143 THDEAVQALKKAGREVILEVKYMREATPYVKKGSPVSEIGWETPPPESPRLG-NTSVCPPSPVAL 206

  Fly   288 TPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNALHSAMGTS 352
            :...|.:.|||::.::.|::...|||||..||||||..|:.:||::|...|..||||:|||....
 Frog   207 SIHGDRKSIPLKMCYVTRSMTVPDPENRNLELHSPDAKHTVVLRSSDPVTAQAWFNAIHSAASDL 271

  Fly   353 TQRALAEANRAL--TNLIG--ELKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVAGELVSP 413
            ..|.:.|....|  |.:.|  ::.|:|||::::.|
 Frog   272 VSRVITEVKEQLGKTGISGSTDIGHLGWLAEKVLG------------------------------ 306

  Fly   414 SGRSSSESSDESDK-WLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRL--AGAGNNSS 475
                      |::| |..:.:.:||::..:|:|.|...:||..|:..|.|..|||  :|.|..||
 Frog   307 ----------ENEKHWKAVLMVLTEKDLLMYDSMPRMKDAWLNPVHAYPLIATRLVHSGPGKISS 361

  Fly   476 LNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFRCLFQGRQCQ 540
            |.|.:.: |..|.|:.:|:..::.|:||:||::.|.||:|||.|.:....:|.|..|.::..:|:
 Frog   362 LPGTEFS-FATRTGSKQGIETHFFRAETNRDLSLWTRSIVQGCHHSAELVKEISTPCTYKNNECR 425

  Fly   541 LVVHINRGFFLYDCGGFAPTTPTV-ATAKTQLWQFAFDKLKGSADDGARMLYLDF-GEDGEIELD 603
            ||::.:.||.|        |:..: .|....|.||.::|||.|:|||.:|||||| |:|||::||
 Frog   426 LVINYDHGFLL--------TSEALDGTYSRPLLQFPYEKLKMSSDDGVKMLYLDFGGKDGELQLD 482

  Fly   604 MECCPKPVVFVVHNCLSAKV 623
            :.|||||:||::|:.||||:
 Frog   483 LHCCPKPIVFIIHSFLSAKI 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	12/30 (40%)
		PDZ_signaling	163..244	CDD:238492	58/80 (73%)
		PHsplit_syntrophin	<293..351	CDD:269960	27/57 (47%)
sntb1	XP_012820630.1	PDZ_signaling	82..163	CDD:238492	58/80 (73%)
		PHsplit_syntrophin	<205..270	CDD:269960	28/64 (44%)
		PH	296..401	CDD:365918	39/145 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	118	1.000	Domainoid score	I5768
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9618
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2011
OMA	1	1.010	-	-		QHG45230
OrthoDB	1	1.010	-	-		D1261897at2759
OrthoFinder	1	1.000	-	-		FOG0003604
OrthoInspector	1	1.000	-	-		otm48201
Panther	1	1.100	-	-	LDO	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2806
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110