DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn1 and whrn

DIOPT Version :9

Sequence 1:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_012824768.2	Gene:	whrn / 100486736	XenbaseID:	XB-GENE-989669	Length:	996	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	92/406 - (22%)
Similarity:	148/406 - (36%)	Gaps:	110/406 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 KRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVNGEELRDATHD 226
            ::.|.::..:.:.||:.|:||.|..:.|.|:.:.:|..|:.| ||.|||.||.:||.......||
Frog   370 EKKVNLVLGEGSSLGLLIRGGAEYSLGIYITGVDKGSEAESA-GLKVGDQILDINGSSFLSIPHD 433

  Fly   227 EAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGW------------------------ELQ 267
            ||||.| .|.|.:.:.|:.:..: |:.|  :|:.|..|                        .|.
Frog   434 EAVRIL-GSSRHLMMTVRDVGRI-PHAR--TIVDETQWLTSSYTGNGEPQPSLGTLSDTSSDSLV 494

  Fly   268 RAFLC--PLGPGVPTSPPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCIL 330
            :...|  |.|..|..|....:|          |.|......|...:||......:        :.
Frog   495 KPVFCRGPTGSQVTLSSLGNQT----------LVLLEEKARLLLTEPERSTMSYY--------LQ 541

  Fly   331 RAAD---SAEALV--WFNALHS-AMGTSTQRALAEANRAL--------TNLIGELKHIGWLSKRM 381
            :..|   |.:||:  .|..|:: |..|:|...|:|....:        .||:.:.:.....|::.
Frog   542 QYKDHHISVQALIMAMFELLNTQAKVTATFSLLSELRSQILPQDLAVFDNLVLKREIESMKSRQR 606

  Fly   382 SGGGSSGSAGGGAASGGSGTSNSVVAGELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESA 446
            |                         |:.||...::.|.||.||.:  .:..|.|.||..:
Frog   607 S-------------------------GDTVSVLSQTLSTSSSESHQ--TVSTASTARERLL---- 640

  Fly   447 PWSVEAWSRPLEIYALATTRLAGAGNNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWA 511
             |.::....        .|...|:.::.||.  |||:..:.......:|     .|......|..
Frog   641 -WLLDVMEN--------GTDPEGSSDSRSLT--QTTLPDISLDDVNSLL-----EEPPNFQPAPP 689

  Fly   512 RSLVQGSHQAVNYQRE 527
            :|.||.:.|.....||
Frog   690 QSAVQNAPQLRRQGRE 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	30/80 (38%)
		PHsplit_syntrophin	<293..351	CDD:269960	12/63 (19%)
whrn	XP_012824768.2	harmonin_N_like	40..117	CDD:416392
		PLN02983	<144..>217	CDD:215533
		PDZ_signaling	231..312	CDD:238492
		PDZ_signaling	370..450	CDD:238492	30/81 (37%)
		HN_L-whirlin_R2_like	513..597	CDD:259823	19/101 (19%)
		PDZ_signaling	905..976	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910