Protein Alignment Syn1 and sntb2

DIOPT Version :9

• Sequence 1: NP_001262192.1
• Gene: Syn1 / 40424
• FlyBaseID: FBgn0037130
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: XP_002666958.1
• Gene: sntb2 / 100331323
• ZFINID: ZDB-GENE-131121-511
• Length: 519
• Species: Danio rerio
• Alignment Length: 610
• Identity: 216/610 - (35%)
• Similarity: 318/610 - (52%)
• Gaps: 127/610 - (20%)

  Fly    32 GNMETRVRGAWYRVLVTLETDFLAVSLDESCEAAQPSNDGQSTTLNGTLGSNHSGGGGGGAGGGG 96
            |:::..:...|.||...|..|.|.::.:                               |..||.
Zfish    12 GHLDLLLSDRWVRVSAELTRDNLTLTAE-------------------------------GEPGGP 45

  Fly    97 TGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDRDPCLNN---NNNAG--DGGGMD-----M 151
            .|....|..|.|..|           :|:..|    ||...|.   :|:.|  :|.|.|     .
Zfish    46 AGYPEHNSHLKNGVS-----------NGNEQN----RDVFTNRVQYDNSPGRVNGTGSDSESSGY 95

  Fly   152 CDVPDHVANQKRHVRIIKSDNNGLGISIKGGRENRMPILISKIFRGMAADQAKGLYVGDAILTVN 216
            ||     :...|.|||:|.::.||||||||||||||||||||||.|:||||::.|.||||||:||
Zfish    96 CD-----SEGVRRVRIVKQESGGLGISIKGGRENRMPILISKIFPGLAADQSRALRVGDAILSVN 155

  Fly   217 GEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPYFRKASIISEVGWE--LQRAFLCPLGPGVP 279
            |.:|||||||.||:|||::|:.|.||||::|||:|.|:|:|:.:::.|:  ||       .|.:.
Zfish   156 GSDLRDATHDAAVQALKKAGKEVTLEVKYIREVSPLFKKSSMSADLSWDGRLQ-------SPNLS 213

  Fly   280 TSPPAPKTTPRADTRYIPLQLTHLARNLKYIDPENRCFELHSPDGVHSCILRAADSAEALVWFNA 344
            :|..:||::...|.:.|||:::.::|||...|||||..|||||||.|:.:||..|.|.|..||.|
Zfish   214 SSDESPKSSVSRDRKVIPLKMSFISRNLTMPDPENRLLELHSPDGQHTVVLRCKDGATAHSWFTA 278

  Fly   345 LHSAMGTSTQRALAEANRALTNLIGE--LKHIGWLSKRMSGGGSSGSAGGGAASGGSGTSNSVVA 407
            :|:.:.....:.|:..|..|.|....  |||||||.:::...||
Zfish   279 IHTNVAALLPQTLSYINTFLNNANTHCTLKHIGWLVEQLDMDGS--------------------- 322

  Fly   408 GELVSPSGRSSSESSDESDKWLPIFVAVTEREFRIYESAPWSVEAWSRPLEIYALATTRLAGAG- 471
                             ..::..:.:|:||::..::::.||:.|:|:.|:..:.|..|||..:|
Zfish   323 -----------------RHQYKRVIMALTEKDILLFQAVPWTYESWTTPVLTHPLLATRLVHSGS 370

  Fly   472 --NNSSLNGQQTTVFCVRCGTARGVLVYWLRSETHRDMAAWARSLVQGSHQAVNYQREFSFRCLF 534
              ::.:|.|.  .:|..|.||.||:..:..|.|||.|::.|.|:||||.|.|....:|.|..|:.
Zfish   371 VRSSPALGGD--LLFATRTGTGRGIESHVFRVETHWDLSTWTRALVQGGHSAAELIKEVSIGCVL 433

  Fly   535 QGRQCQLVVHINRGFFLYDCGGFAPTTPTVATAKTQLWQFAFDKLKGSADDGARMLYLDFG-EDG 598
            ..:..:|::|..|||           |.|..:..:.|:.|.:::||.|||||.|.|:|||| .:|
Zfish   434 NRQNVRLILHYERGF-----------TVTRESGDSVLFHFPYERLKMSADDGVRNLFLDFGAPEG 487

  Fly   599 EIELDMECCPKPVVFVVHNCLSAKV 623
            |:..::...|||||||:|:.||||:
Zfish   488 EMVFELHSGPKPVVFVLHSFLSAKL 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622	7/28 (25%)
		PDZ_signaling	163..244	CDD:238492	58/80 (73%)
		PHsplit_syntrophin	<293..351	CDD:269960	28/57 (49%)
sntb2	XP_002666958.1	PDZ_signaling	101..183	CDD:238492	58/81 (72%)
		PHsplit_syntrophin	<228..285	CDD:269960	28/56 (50%)
		PH	307..415	CDD:278594	38/147 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576810
Domainoid	1	1.000	139	1.000	Domainoid score	I4777
eggNOG	1	0.900	-	-		E1_KOG3551
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2290
OMA	1	1.010	-	-		QHG45230
OrthoDB	1	1.010	-	-		D1261897at2759
OrthoFinder	1	1.000	-	-		FOG0003604
OrthoInspector	1	1.000	-	-		otm25219
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2806
SonicParanoid	1	1.000	-	-		X1403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.900