DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF432

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001309213.1	Gene:	ZNF432 / 9668	HGNCID:	20810	Length:	652	Species:	Homo sapiens

Alignment Length:	413	Identity:	123/413 - (29%)
Similarity:	174/413 - (42%)	Gaps:	80/413 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHIT 141
            |:.|..|..|  ..|:||||:|.|.|..|:.|..|..:|:.|:|:.|..|.|.:.:...|..| .
Human   191 QVSKHQRTHE--IEKNHVCSECGKAFVKKSQLTDHERVHTGEKPYGCTLCAKVFSRKSRLNEH-Q 252

  Fly   142 TAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQ 206
            ..|:..|.|:||:|.|.|.:|.||..|.|.|:|||||.|:.|.|.|.....|..|..:|  |..:
Human   253 RIHKREKSFICSECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNH--TGEK 315

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANE----LALRAHINQE--------- 258
            .:.|::|...|:..:.|.:|...|.....:.||.|...|..:    :..|.|..::
Human   316 SYICSECGKGFTGKSMLIIHQRTHTGEKPYICSECGKGFTTKHYVIIHQRNHTGEKPYICNECGK 380

  Fly   259 ---------HHKLTQ-----FECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYN 309
                     .|:.|.     :.|..|.|......:|..|.:.||..|:::|..|...||.||...
Human   381 GFTMKSRMIEHQRTHTGEKPYICSECGKGFPRKSNLIVHQRNHTVEKSYLCSECGKGFTVKSMLI 445

  Fly   310 VHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDE--VAFSQLAHLKNHM-- 370
            :|.|.||||:||.|..|.:.|...|.|.:|.|.||||||:||..|...  |....:.|.:.|.
Human   446 IHQRTHTGEKPYTCSECGKGFPLKSRLIVHQRTHTGEKPYRCSECGKGFIVNSGLMLHQRTHTGE 510

  Fly   371 ---------------------KKIHKQQKPYMCEGCHDFFKIK----VELQSHVEH----CAKC- 405
                                 ::.|..:||:||..|...|.:|    |..|.|.|.    |::|
Human   511 KPYICNECGKGFAFKSNLVVHQRTHTGEKPFMCSECGKGFTMKRYLIVHQQIHTEEKSCICSECG 575

  Fly   406 --------------PVDGDKPSG 414
                          ...|:||.|
Human   576 RGFAKETELALHKQVHTGEKPYG 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/158 (35%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	8/24 (33%)
		C2H2 Zn finger	123..144	CDD:275368	5/20 (25%)
		C2H2 Zn finger	152..172	CDD:275368	10/19 (53%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	58/205 (28%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/43 (14%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	5/47 (11%)
		C2H2 Zn finger	382..399	CDD:275368	6/20 (30%)
ZNF432	NP_001309213.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<87..380	CDD:227381	62/193 (32%)
		C2H2 Zn finger	207..227	CDD:275368	8/19 (42%)
		C2H2 Zn finger	235..255	CDD:275368	5/20 (25%)
		COG5048	259..636	CDD:227381	99/342 (29%)
		C2H2 Zn finger	263..283	CDD:275368	10/19 (53%)
		C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		zf-H2C2_2	331..356	CDD:290200	7/24 (29%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	1/19 (5%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		zf-H2C2_2	443..466	CDD:290200	10/22 (45%)
		C2H2 Zn finger	459..479	CDD:275368	7/19 (37%)
		zf-H2C2_2	472..494	CDD:290200	12/21 (57%)
		C2H2 Zn finger	487..507	CDD:275368	4/19 (21%)
		zf-H2C2_2	500..523	CDD:290200	2/22 (9%)
		C2H2 Zn finger	515..535	CDD:275368	0/19 (0%)
		zf-H2C2_2	527..551	CDD:290200	6/23 (26%)
		C2H2 Zn finger	543..563	CDD:275368	6/19 (32%)
		C2H2 Zn finger	571..591	CDD:275368	2/19 (11%)
		C2H2 Zn finger	599..619	CDD:275368	123/413 (30%)
		zf-H2C2_2	612..636	CDD:290200
		C2H2 Zn finger	627..647	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910