DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF585B

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_689492.3	Gene:	ZNF585B / 92285	HGNCID:	30948	Length:	769	Species:	Homo sapiens

Alignment Length:	352	Identity:	116/352 - (32%)
Similarity:	169/352 - (48%)	Gaps:	40/352 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNL----------------- 136
            :.|..:|::|.|.|..:::|..|..||:.|:|::|.|||:::.|...|
Human   350 REKSSICTECGKAFTYRSELIIHQRIHTGEKPYECSDCGRAFTQKSALTVHQRIHTGEKSYICMK 414

  Fly   137 -------KNHITT---AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGG 191
                   |.|:.|   .|...|.:.|..|.|.|..|.:|.:|.|:|:|||||.|:.|.|.|....
Human   415 CGLAFIRKAHLITHQIIHTGEKPYKCGHCGKLFTSKSQLHVHKRIHTGEKPYVCNKCGKAFTNRS 479

  Fly   192 QLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHIN 256
            .|..|..:|  |..:.:.|:||..:|:..::|..|...|.....:.|:.|...|..:..|..| .
Human   480 NLITHQKTH--TGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPYECNTCGKAFTQKSNLNIH-Q 541

  Fly   257 QEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPY 321
            :.|....|:||..|.|.......|..|.:.||..|.:||..|...|.:||.:..|.|:||||:||
Human   542 KIHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIRKSNFITHQRIHTGEKPY 606

  Fly   322 QCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCH 386
            :|..|.::|...|.|.:|...||||||:.|..|..  |||..::|..| :|.|..:|||:|..|.
Human   607 ECSDCGKSFTSKSQLLVHQPVHTGEKPYVCAECGK--AFSGRSNLSKH-QKTHTGEKPYICSECG 668

  Fly   387 DFFKIKVELQSHVE-HCAKCPVDGDKP 412
            ..|:.|.||.:|.. |      .|:||
Human   669 KTFRQKSELITHHRIH------TGEKP 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/184 (29%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	9/47 (19%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	59/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
ZNF585B	NP_689492.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	132..152	CDD:275368
		COG5048	156..529	CDD:227381	53/180 (29%)
		C2H2 Zn finger	160..180	CDD:275368
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	216..236	CDD:275368
		zf-H2C2_2	228..253	CDD:290200
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368
		C2H2 Zn finger	300..320	CDD:275368
		C2H2 Zn finger	328..347	CDD:275368
		COG5048	335..768	CDD:227381	116/352 (33%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
		zf-H2C2_2	368..393	CDD:290200	10/24 (42%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	3/19 (16%)
		zf-H2C2_2	424..449	CDD:290200	8/24 (33%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		zf-H2C2_2	455..477	CDD:290200	12/21 (57%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		C2H2 Zn finger	496..516	CDD:275368	6/19 (32%)
		zf-H2C2_2	508..533	CDD:290200	6/24 (25%)
		C2H2 Zn finger	524..544	CDD:275368	5/20 (25%)
		zf-H2C2_2	536..561	CDD:290200	8/25 (32%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		zf-H2C2_2	565..589	CDD:290200	9/23 (39%)
		C2H2 Zn finger	580..600	CDD:275368	7/19 (37%)
		zf-H2C2_2	592..617	CDD:290200	11/24 (46%)
		C2H2 Zn finger	608..628	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	8/22 (36%)
		zf-H2C2_2	648..673	CDD:290200	10/25 (40%)
		C2H2 Zn finger	664..684	CDD:275368	7/19 (37%)
		zf-H2C2_2	676..700	CDD:290200	7/20 (35%)
		C2H2 Zn finger	692..712	CDD:275368
		zf-H2C2_2	705..729	CDD:290200
		C2H2 Zn finger	720..740	CDD:275368
		zf-H2C2_2	732..757	CDD:290200
		C2H2 Zn finger	748..768	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000