DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF845

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	449	Identity:	143/449 - (31%)
Similarity:	207/449 - (46%)	Gaps:	63/449 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RKSSLASLRDACVDEEE---DDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGK 105
            |||||...|.....|:.   :|.|:..|:....|   ..:....||    |.:.|.:|.:.|..|
Human   394 RKSSLTRHRRLHTGEKPYKCNDCGKTFSQMSSLV---YHRRLHTGE----KPYKCEECDEAFSFK 451

  Fly   106 TDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMR 170
            ::|:||..||:.|:|:||.||||::.|..:|..| ...|...|.:.|.:|.::|:.|..|..|..
Human   452 SNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVYH-RRLHTGEKPYKCEECDEAFSFKSNLERHRI 515

  Fly   171 LHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGME 235
            :|:|||.|.|:.|.|.|:|...|.:|...|  |..:.:.|.:|..:|...:.|..|...|..|..
Human   516 IHTGEKLYKCNECGKTFSRKSSLTRHCRLH--TGEKPYQCNECGKAFRGQSALIYHQAIHGIGKL 578

  Fly   236 HRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNT 300
            ::|:.|...|:|...:..|. :.|::...::|..|.|.......||.|.:.|:..|.:.||.|:.
Human   579 YKCNDCHQVFSNATTIANHW-RIHNEERSYKCNRCGKFFRHRSYLAVHWRTHSGEKPYKCEECDE 642

  Fly   301 YFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLC----------- 354
            .|:.||....|.|:||||:||:|..|.:||:..|.|..|.|.||||||::|..|
Human   643 AFSFKSNLQRHRRIHTGEKPYRCNECGKTFSRKSYLTCHRRLHTGEKPYKCNECGKTFGRNSALI 707

  Fly   355 ---------------EDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-----V 399
                           |...||||.:.|..|: ::|..:|||.||.|...|..|..|:.|     .
Human   708 IHKAIHTGEKPYKCNECGKAFSQKSSLTCHL-RLHTGEKPYKCEECDKVFSRKSSLEKHRRIHTG 771

  Fly   400 EHCAKCPVDGDKPSGNQSEDAQILSV---------------LRFNMAVVL-KKISSAQK 442
            |...||.| .||..|..|..||...:               .|.|.|:|: |.|.|.:|
Human   772 EKPYKCKV-CDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFRHNSALVIHKAIHSGEK 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	13/24 (54%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	61/202 (30%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	9/48 (19%)
		C2H2 Zn finger	382..399	CDD:275368	7/21 (33%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	59/179 (33%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		C2H2 Zn finger	301..321	CDD:275368
		C2H2 Zn finger	329..349	CDD:275368
		C2H2 Zn finger	357..377	CDD:275368
		zf-H2C2_2	369..394	CDD:290200	143/449 (32%)
		COG5048	381..813	CDD:227381	135/431 (31%)
		C2H2 Zn finger	385..405	CDD:275368	6/10 (60%)
		zf-H2C2_2	397..422	CDD:290200	6/24 (25%)
		C2H2 Zn finger	413..433	CDD:275368	4/22 (18%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..478	CDD:290200	13/24 (54%)
		C2H2 Zn finger	469..489	CDD:275368	8/20 (40%)
		C2H2 Zn finger	497..517	CDD:275368	6/19 (32%)
		zf-H2C2_2	509..534	CDD:290200	11/24 (46%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		zf-H2C2_2	537..560	CDD:290200	6/24 (25%)
		C2H2 Zn finger	553..573	CDD:275368	5/19 (26%)
		C2H2 Zn finger	581..601	CDD:275368	5/20 (25%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		C2H2 Zn finger	637..657	CDD:275368	8/19 (42%)
		zf-H2C2_2	649..674	CDD:290200	12/24 (50%)
		C2H2 Zn finger	665..685	CDD:275368	8/19 (42%)
		C2H2 Zn finger	693..713	CDD:275368	2/19 (11%)
		C2H2 Zn finger	721..741	CDD:275368	7/20 (35%)
		C2H2 Zn finger	749..769	CDD:275368	7/19 (37%)
		zf-H2C2_2	761..786	CDD:290200	8/25 (32%)
		C2H2 Zn finger	777..797	CDD:275368	8/20 (40%)
		C2H2 Zn finger	805..825	CDD:275368	5/19 (26%)
		C2H2 Zn finger	833..853	CDD:275368
		zf-H2C2_2	845..870	CDD:290200
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000