DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF682

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_016882944.1	Gene:	ZNF682 / 91120	HGNCID:	28857	Length:	504	Species:	Homo sapiens

Alignment Length:	439	Identity:	131/439 - (29%)
Similarity:	192/439 - (43%)	Gaps:	60/439 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SVSKEDAVSLL--------TDSGISLSSPPAARESSPGPTL-----------AIKRRKSSLASLR 52
            :|||.:.:|.|        .....:::.|||.........|           .|.||..| ..|.
Human    52 TVSKPELISRLEQRQEPWNVKRHETIAKPPAMSSHYTEDLLPEQCMQDSFQKVILRRYGS-CGLE 115

  Fly    53 DACVDEEEDDGGE-QDSKD-------------------DDYVQPQLKKSARKGEPVK---RKHHV 94
            |..:.::.::.|| :|.|:                   :..|:...|.|....|.::   .|...
Human   116 DLHLRKDGENVGECKDQKEIYNGLNQCLSTLPSKIFPYNKCVKVFSKSSNLNRENIRHTTEKLFK 180

  Fly    95 CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSF 159
            |.||.|.|...:.|..|.:||::|:...|::|||:::....|..| ...|...|.:.|.:|.|:|
Human   181 CMQCGKVFKSHSGLSYHKIIHTEEKLCICEECGKTFKWFSYLTKH-KRIHTGEKPYKCEECGKAF 244

  Fly   160 ALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLR 224
            .....|..|.|:|:|||||.|:.|.|.|.......:|...|  |..:.:.|..|..:|:.:::|.
Human   245 NWCSSLTKHKRIHTGEKPYKCEECGKAFHWCSPFVRHKKIH--TGEKPYTCEDCGRAFNRHSHLT 307

  Fly   225 VHMERHEQGMEHRCSICENQFANELAL-----RAHINQEHHKLTQFECEICHKMIEPDEDLATHM 284
            .|...|.....::|..|...| |..:|     |.|..::.:|     ||.|.|.......|..|.
Human   308 KHKTIHTGKKPYKCKECGKAF-NHCSLLTIHERTHTGEKPYK-----CEECGKAFNSSSILTEHK 366

  Fly   285 QRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPF 349
            ..|:..|.:.||.|:..|.:.|....|.|:||||:||:|..|.:.|..||:|..|.|.||||||:
Human   367 VIHSGEKPYKCEKCDKVFKRFSYLTKHKRIHTGEKPYKCEECGKAFNWSSILTEHKRIHTGEKPY 431

  Fly   350 RCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            .|:.|..  ||::.:||..| ||||...|.|.||.|...||....|..|
Human   432 NCEECGK--AFNRCSHLTRH-KKIHTAVKRYKCEECGKAFKRCSHLNEH 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	48/161 (30%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	<192..369	CDD:227381	58/181 (32%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	7/26 (27%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	7/17 (41%)
ZNF682	XP_016882944.1	KRAB	10..70	CDD:214630	5/17 (29%)
		KRAB	10..49	CDD:279668
		C2H2 Zn finger	153..173	CDD:275368	4/19 (21%)
		C2H2 Zn finger	181..201	CDD:275368	7/19 (37%)
		C2H2 Zn finger	209..229	CDD:275368	6/20 (30%)
		zf-H2C2_2	221..245	CDD:290200	7/24 (29%)
		C2H2 Zn finger	237..257	CDD:275368	7/19 (37%)
		COG5048	<245..451	CDD:227381	72/216 (33%)
		zf-H2C2_2	249..273	CDD:290200	12/23 (52%)
		C2H2 Zn finger	265..285	CDD:275368	5/19 (26%)
		zf-H2C2_2	280..302	CDD:290200	6/23 (26%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		zf-H2C2_2	305..330	CDD:290200	6/25 (24%)
		C2H2 Zn finger	321..341	CDD:275368	6/20 (30%)
		zf-H2C2_2	334..358	CDD:290200	7/28 (25%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		zf-H2C2_2	362..386	CDD:290200	8/23 (35%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	389..413	CDD:290200	10/23 (43%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		zf-H2C2_2	418..442	CDD:290200	13/25 (52%)
		C2H2 Zn finger	433..453	CDD:275368	9/22 (41%)
		zf-H2C2_2	445..470	CDD:290200	13/25 (52%)
		C2H2 Zn finger	461..480	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000