DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF616

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_848618.2	Gene:	ZNF616 / 90317	HGNCID:	28062	Length:	781	Species:	Homo sapiens

Alignment Length:	543	Identity:	141/543 - (25%)
Similarity:	230/543 - (42%)	Gaps:	135/543 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GIS----LSSPPAARESSPG---PTLAIKRRKS-SLASL-----------------------RDA 54
            |||    :...|....|:.|   .|:|::|.:| .:.:|                       ::.
Human    47 GISPKCVIKELPPTENSNTGERFQTVALERHQSYDIENLYFREIQKHLHDLEFQWKDGETNDKEV 111

  Fly    55 CVDEEEDDGGEQDSK-----DDDYVQPQL--------------------------KKSARKG--- 85
            .|..|.:..|::|..     ::::::.||                          :|:...|
Human   112 PVPHENNLTGKRDQHSQGDVENNHIENQLTSNFESRLAELQKVQTEGRLYECNETEKTGNNGCLV 176

  Fly    86 EP-VKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITT------- 142
            .| ::.|.:||::|.|.|...:.|..|..||:.|:|:||.:|||::.:|..|..|...
Human   177 SPHIREKTYVCNECGKAFKASSSLINHQRIHTTEKPYKCNECGKAFHRASLLTVHKVVHTRGKSY 241

  Fly   143 --------------------AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKF 187
                                :|..:|.::|::|.|||:....|.:|.|:|:|||||.|:||.|.|
Human   242 QCDVCGKIFRKNSYFVRHQRSHTGQKPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNLCGKSF 306

  Fly   188 ARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELAL- 251
            ::...|:.|...|  |..:.|.|.:|..:|..::||.||...|.....::|.:|...|.:...|
Human   307 SQRVHLRLHQTVH--TGERPFKCNECGKTFKRSSNLTVHQVIHAGKKPYKCDVCGKAFRHRSNLV 369

  Fly   252 ---RAHINQEHHKLTQ-----------------------FECEICHKMIEPDEDLATHMQRHTAV 290
               |.|..::.:|..:                       .:|..|.|:......||.|.:.||..
Human   370 CHRRIHSGEKQYKCNECGKVFSKRSSLAVHRRIHTVEKPCKCNECGKVFSKRSSLAVHQRIHTGQ 434

  Fly   291 KTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCE 355
            ||:.|..|...:::.|...||.|:||||:.|:|..|.:.|:..|.|..|.|.||||||::|..|.
Human   435 KTYKCNKCGKVYSKHSHLAVHWRIHTGEKAYKCNECGKVFSIHSRLAAHQRIHTGEKPYKCNECG 499

  Fly   356 DEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDGDKPSGNQSED 419
            .  .|||.:.|..| ::||..:|||.|:.|...|..:.....|.. |      .|:||. ...|.
Human   500 K--VFSQHSRLAVH-RRIHTGEKPYKCKECGKVFSDRSAFARHRRIH------TGEKPY-KCKEC 554

  Fly   420 AQILSVLRFNMAVVLKKISSAQK 442
            .::.|  :.:...|.::|.|.:|
Human   555 GKVFS--QCSRLTVHRRIHSGEK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/185 (31%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/47 (15%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/203 (30%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/25 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	3/16 (19%)
ZNF616	NP_848618.2	KRAB	7..61	CDD:214630	4/13 (31%)
		KRAB	7..46	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	105..129		4/23 (17%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		zf-H2C2_2	199..224	CDD:290200	11/24 (46%)
		C2H2 Zn finger	243..263	CDD:275368	0/19 (0%)
		COG5048	266..707	CDD:227381	100/324 (31%)
		C2H2 Zn finger	271..291	CDD:275368	8/19 (42%)
		zf-H2C2_2	283..308	CDD:290200	14/24 (58%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		zf-H2C2_2	311..336	CDD:290200	8/26 (31%)
		C2H2 Zn finger	327..347	CDD:275368	7/19 (37%)
		C2H2 Zn finger	355..375	CDD:275368	5/19 (26%)
		C2H2 Zn finger	383..403	CDD:275368	0/19 (0%)
		C2H2 Zn finger	411..431	CDD:275368	6/19 (32%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		zf-H2C2_2	480..504	CDD:290200	12/25 (48%)
		C2H2 Zn finger	495..515	CDD:275368	7/22 (32%)
		zf-H2C2_2	508..531	CDD:290200	9/23 (39%)
		C2H2 Zn finger	523..543	CDD:275368	4/19 (21%)
		zf-H2C2_2	538..560	CDD:290200	7/30 (23%)
		C2H2 Zn finger	551..571	CDD:275368	3/21 (14%)
		C2H2 Zn finger	579..599	CDD:275368
		zf-H2C2_2	591..616	CDD:290200
		C2H2 Zn finger	607..627	CDD:275368
		zf-H2C2_2	620..644	CDD:290200
		C2H2 Zn finger	635..655	CDD:275368
		zf-H2C2_2	647..672	CDD:290200
		C2H2 Zn finger	663..683	CDD:275368
		C2H2 Zn finger	691..711	CDD:275368
		zf-H2C2_2	703..728	CDD:290200
		C2H2 Zn finger	719..739	CDD:275368
		zf-H2C2_2	731..754	CDD:290200
		C2H2 Zn finger	747..767	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000