DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF30

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001092907.1	Gene:	ZNF30 / 90075	HGNCID:	13090	Length:	624	Species:	Homo sapiens

Alignment Length:	352	Identity:	115/352 - (32%)
Similarity:	167/352 - (47%)	Gaps:	24/352 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|.:|.|.|...:.|.:|..||:.|:|::||:||||:.....|..| .:.|...|.|.|.:|
Human   287 KPYECKECGKAFSTSSPLAKHQRIHTGEKPYECKECGKSFTVYGQLTRH-QSIHTGEKPFECKEC 350

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220
            .|:|.|...|..|.|:|:..|||.|..|.:.|:|...|.||...|  |..:.:.|.:|..:|||.
Human   351 GKAFRLSSFLHAHQRIHAEIKPYGCKECGRTFSRASYLVQHGRLH--TGEKPYECKECGKAFSTG 413

  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQ 285
            :.|..|...|.....:.|..|...|.:...|..| .:.|.....:||:.|.|.......|..|.:
Human   414 SYLVQHQRIHTGEKPYECKECGKAFISRHQLTVH-QRVHTGEKPYECKECGKAFRVHVHLTQHRK 477

  Fly   286 RHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFR 350
            .||.||.:.|:.|...|::.|....|.|:|||::||:|:.|.:.|:..|.|..|.|.||||||:.
Human   478 IHTDVKPYECKECGKTFSRASYLVQHSRIHTGKKPYECKECGKAFSSGSYLVQHQRIHTGEKPYE 542

  Fly   351 CQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE--------HCAKCPV 407
            |..|..  ||:....|..| :.:|..:||:.|:.|...|::...|..|..        .|.||
Human   543 CNKCGK--AFTVYGQLIGH-QSVHTGEKPFECKECGKAFRLNSFLTEHQRVHTGEKPFKCKKC-- 602

  Fly   408 DGDKPSGNQSEDAQILSV-LRFNMAVV 433
                  |.....:..|.| ||.:|:|:
Human   603 ------GKTFRYSSALKVHLRKHMSVI 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/155 (35%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	10/23 (43%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF30	NP_001092907.1	KRAB	14..75	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	<97..302	CDD:227381	5/14 (36%)
		C2H2 Zn finger	123..143	CDD:275368
		C2H2 Zn finger	151..171	CDD:275368
		C2H2 Zn finger	179..199	CDD:275368
		C2H2 Zn finger	207..227	CDD:275368
		C2H2 Zn finger	235..255	CDD:275368
		COG5048	245..624	CDD:227381	115/352 (33%)
		C2H2 Zn finger	263..283	CDD:275368
		zf-H2C2_2	275..300	CDD:290200	5/12 (42%)
		C2H2 Zn finger	291..311	CDD:275368	6/19 (32%)
		zf-H2C2_2	304..327	CDD:290200	12/22 (55%)
		C2H2 Zn finger	319..339	CDD:275368	8/20 (40%)
		zf-H2C2_2	332..354	CDD:290200	8/22 (36%)
		C2H2 Zn finger	347..367	CDD:275368	8/19 (42%)
		C2H2 Zn finger	375..395	CDD:275368	7/19 (37%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		zf-H2C2_2	415..438	CDD:290200	5/22 (23%)
		C2H2 Zn finger	431..451	CDD:275368	5/20 (25%)
		zf-H2C2_2	444..466	CDD:290200	7/22 (32%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		zf-H2C2_2	471..496	CDD:290200	9/24 (38%)
		C2H2 Zn finger	487..507	CDD:275368	6/19 (32%)
		zf-H2C2_2	499..524	CDD:290200	10/24 (42%)
		C2H2 Zn finger	515..535	CDD:275368	7/19 (37%)
		zf-H2C2_2	527..551	CDD:290200	12/25 (48%)
		C2H2 Zn finger	543..563	CDD:275368	6/22 (27%)
		C2H2 Zn finger	571..591	CDD:275368	5/19 (26%)
		zf-H2C2_2	584..608	CDD:290200	6/31 (19%)
		C2H2 Zn finger	599..619	CDD:275368	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910