DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF607

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_116078.4	Gene:	ZNF607 / 84775	HGNCID:	28192	Length:	696	Species:	Homo sapiens

Alignment Length:	362	Identity:	116/362 - (32%)
Similarity:	172/362 - (47%)	Gaps:	47/362 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAH 144
            :|...||    |...|::|.|.|..|..|:.|..||:.|:||:||:|||::||..:|..| ...|
Human   244 QSIHTGE----KPFECNKCGKSFRLKAGLKVHQSIHTGEKPHECKECGKAFRQFSHLVGH-KRIH 303

  Fly   145 EHRKQFVCSQCPKSFALKERLRLHMRLHSG----------------------------EKPYPCD 181
            ...|.:.|.:|.|.|..:.:|.:|.|::||                            ||||.|:
Human   304 TGEKPYECKECGKGFTCRYQLTMHQRIYSGEKHYECKENGEAFSSGHQLTAPHTFESVEKPYKCE 368

  Fly   182 LCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFA 246
            .|.|.|:..|:|.:|...|  :..:.:.|.||..||..|::|::|...|.....::|..|...|:
Human   369 ECGKAFSVHGRLTRHQGIH--SGKKPYECNKCGKSFRLNSSLKIHQNIHTGEKPYKCKECGKAFS 431

  Fly   247 NELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVH 311
            ....| ||.|:.|.....|||:.|.|.......|..|.:.||..|.:||:.|...|:...:..:|
Human   432 QRAHL-AHHNRIHTGYKPFECKECGKSFRCASYLVIHERIHTGEKPYVCQECGKGFSYSHKLTIH 495

  Fly   312 MRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQ 376
            .|:||||:||:|:.|.:.|:.|..|..|:..|:|:|||.|..|.....|  ::.||.| :.||..
Human   496 RRVHTGEKPYECKECGKAFSVSGQLTQHLSIHSGKKPFECNKCGKSFRF--ISVLKAH-QNIHSA 557

  Fly   377 QKPYMCEGCHDFFKIKVELQSHVE--------HCAKC 405
            :|||.|:.|...|:....|..|..        .|.:|
Human   558 EKPYECKECGKAFRHATSLIYHDRTHAGEKSYECKEC 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/186 (31%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/51 (25%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF607	NP_116078.4	KRAB	7..67	CDD:214630
		KRAB	7..45	CDD:279668
		C2H2 Zn finger	116..136	CDD:275368
		C2H2 Zn finger	144..164	CDD:275368
		C2H2 Zn finger	172..192	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..247	CDD:275368	1/2 (50%)
		zf-H2C2_2	240..262	CDD:290200	7/21 (33%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..292	CDD:290200	12/23 (52%)
		COG5048	279..687	CDD:227381	102/323 (32%)
		C2H2 Zn finger	283..303	CDD:275368	9/20 (45%)
		zf-H2C2_2	295..320	CDD:290200	8/25 (32%)
		C2H2 Zn finger	311..330	CDD:275368	6/18 (33%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..415	CDD:275368	8/19 (42%)
		zf-H2C2_2	407..432	CDD:290200	6/24 (25%)
		C2H2 Zn finger	423..443	CDD:275368	7/20 (35%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		zf-H2C2_2	463..488	CDD:290200	9/24 (38%)
		C2H2 Zn finger	479..499	CDD:275368	5/19 (26%)
		zf-H2C2_2	492..515	CDD:290200	10/22 (45%)
		C2H2 Zn finger	507..527	CDD:275368	6/19 (32%)
		C2H2 Zn finger	535..555	CDD:275368	6/22 (27%)
		C2H2 Zn finger	563..583	CDD:275368	5/19 (26%)
		C2H2 Zn finger	591..611	CDD:275368	2/4 (50%)
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000