DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF559

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001189335.1	Gene:	ZNF559 / 84527	HGNCID:	28197	Length:	602	Species:	Homo sapiens

Alignment Length:	400	Identity:	118/400 - (29%)
Similarity:	188/400 - (47%)	Gaps:	70/400 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RKSSLASL-RDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHV------CSQCSKE 101
            ||.|:.:| :...:.||..:..:.::....::....||:::....|.:|.|.      ||.|.|.
Human   193 RKPSIFTLHKKTDIGEELPNCNQCETAFSQHLHLVCKKTSQNLHLVCKKTHTQEKPYKCSDCEKG 257

  Fly   102 FGGKTDLQRHMLIHSDERP--HK--------------------------CKDCGKSYRQAVNLKN 138
            ....:.|:..:.|:..|||  ||                          ||.|||.:.::..|..
Human   258 LPSSSHLRECVRIYGGERPYTHKEYVETFSHSTALFVHMQTQDGEKFYECKACGKPFTESSYLTQ 322

  Fly   139 HITTAH------EHR----------------------KQFVCSQCPKSFALKERLRLHMRLHSGE 175
            |:.| |      ||:                      |.:||::|.|.|....:|.:|:|:|:||
Human   323 HLRT-HSRVLPIEHKKFGKAFAFSPDLAKHIRLRTRGKHYVCNECGKEFTCFSKLNIHIRVHTGE 386

  Fly   176 KPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSI 240
            |||.|:.|.|.|.....|.:|..:|  |..:.:.|.:|..:|:.:::|.|||..|.....::|..
Human   387 KPYECNKCGKAFTDSSGLIKHRRTH--TGEKPYECKECGKAFANSSHLTVHMRTHTGEKPYQCKE 449

  Fly   241 CENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQK 305
            |...|.|..:.::|: |.|..:..::|:.|.|.......|..|::.|:|.:...||.|...|...
Human   450 CGKAFINSSSFKSHM-QTHPGVKPYDCQQCGKAFIRSSFLIRHLRSHSAERPFECEECGKAFRYS 513

  Fly   306 SQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHM 370
            |..:.|.|:|||||||:|:.|.|.|:.||.|.:|:|.||||:||.||.|..  ||::..:|..|:
Human   514 SHLSQHKRIHTGERPYKCQKCGQAFSISSGLTVHMRTHTGERPFECQECGK--AFTRSTYLIRHL 576

  Fly   371 KKIHKQQKPY 380
            :. |..:|||
Human   577 RS-HSVEKPY 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	59/220 (27%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	12/52 (23%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	61/176 (35%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	13/22 (59%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368
ZNF559	NP_001189335.1	KRAB	78..>118	CDD:214630
		KRAB	78..117	CDD:279668
		C2H2 Zn finger	158..177	CDD:275368
		C2H2 Zn finger	185..240	CDD:275368	9/46 (20%)
		COG5048	212..601	CDD:227381	111/380 (29%)
		C2H2 Zn finger	213..243	CDD:275368	4/29 (14%)
		C2H2 Zn finger	251..299	CDD:275368	11/47 (23%)
		C2H2 Zn finger	307..327	CDD:275368	8/20 (40%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-H2C2_2	376..399	CDD:290200	12/22 (55%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	404..428	CDD:290200	7/25 (28%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		zf-H2C2_2	431..454	CDD:290200	7/22 (32%)
		zf-C2H2	445..467	CDD:278523	6/22 (27%)
		C2H2 Zn finger	447..467	CDD:275368	6/20 (30%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		zf-H2C2_2	488..512	CDD:290200	8/23 (35%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		zf-H2C2_2	515..539	CDD:290200	12/23 (52%)
		C2H2 Zn finger	531..551	CDD:275368	9/19 (47%)
		zf-H2C2_2	544..568	CDD:290200	14/25 (56%)
		C2H2 Zn finger	559..579	CDD:275368	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910