DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF528

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_006723481.1	Gene:	ZNF528 / 84436	HGNCID:	29384	Length:	712	Species:	Homo sapiens

Alignment Length:	323	Identity:	108/323 - (33%)
Similarity:	161/323 - (49%)	Gaps:	15/323 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|.:|.|.|...::|.:|..||:.|:|:||.:|.|.:|.:..|..| ...|...|.:.|.:|
Human   323 KPYKCHECGKLFSSNSNLSQHQRIHTGEKPYKCHECDKVFRSSSKLAQH-QRIHTGEKPYKCHEC 386

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220
            .|.|.....|..|.::|:|||||.|:.|.|.|:|...|.:|...|  |..:.:.|.:|..:||..
Human   387 DKVFNQIAHLVRHQKIHTGEKPYSCNKCGKVFSRHSYLAEHQTVH--TGEKPYKCEECGKAFSVR 449

  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQ 285
            ::|..|...|.....::|..|:..|..:..|.:| .:.|.:...:.|..|.|:.....||..|.:
Human   450 SSLITHQLIHTGRKPYKCKECDKVFGRKCFLTSH-QRIHTRERPYGCSQCGKIFSQKSDLIRHRK 513

  Fly   286 RHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFR 350
            .||..|.:.|..|.|.|.:.|....|..:|:||:||:|:.|.:.|.:.|.|..|.|.||||||::
Human   514 THTDEKPYKCNKCGTAFREFSDLTAHFLIHSGEKPYECKECGKVFRYKSSLTSHHRIHTGEKPYK 578

  Fly   351 CQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-VEH-------CAKC 405
            |..|..  .||:.::|..| :|||..:|||.|..|...|.....|..| :.|       |:||
Human   579 CNRCGK--VFSRSSNLVCH-QKIHTGEKPYKCNQCGKVFNQASYLTRHQIIHTGERPYRCSKC 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	51/155 (33%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	55/176 (31%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF528	XP_006723481.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	272..291	CDD:275368
		COG5048	277..712	CDD:227381	108/323 (33%)
		C2H2 Zn finger	299..319	CDD:275368
		zf-H2C2_2	312..336	CDD:290200	5/12 (42%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..364	CDD:290200	10/24 (42%)
		C2H2 Zn finger	355..375	CDD:275368	6/20 (30%)
		zf-H2C2_2	368..392	CDD:290200	8/24 (33%)
		C2H2 Zn finger	383..403	CDD:275368	6/19 (32%)
		zf-H2C2_2	395..420	CDD:290200	12/24 (50%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		zf-H2C2_2	423..447	CDD:290200	6/25 (24%)
		C2H2 Zn finger	439..459	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..487	CDD:275368	5/20 (25%)
		C2H2 Zn finger	495..515	CDD:275368	6/19 (32%)
		C2H2 Zn finger	523..543	CDD:275368	6/19 (32%)
		zf-H2C2_2	535..560	CDD:290200	9/24 (38%)
		C2H2 Zn finger	551..571	CDD:275368	7/19 (37%)
		zf-H2C2_2	563..588	CDD:290200	12/26 (46%)
		C2H2 Zn finger	579..599	CDD:275368	7/22 (32%)
		zf-H2C2_2	591..616	CDD:290200	11/25 (44%)
		C2H2 Zn finger	607..627	CDD:275368	5/19 (26%)
		zf-H2C2_2	619..642	CDD:290200	6/20 (30%)
		C2H2 Zn finger	635..655	CDD:275368	3/4 (75%)
		C2H2 Zn finger	663..683	CDD:275368
		zf-H2C2_2	675..700	CDD:290200
		C2H2 Zn finger	691..711	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910