DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF93

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_112495.2	Gene:	ZNF93 / 81931	HGNCID:	13169	Length:	620	Species:	Homo sapiens

Alignment Length:	361	Identity:	122/361 - (33%)
Similarity:	174/361 - (48%)	Gaps:	31/361 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQ 154
            :|.:.|.:|.|.|...:.|.:|..||:.|:|:||::|||::.|:..|..| ...|...|.:||.:
Human   254 KKPYKCEECGKAFNQSSTLTKHKKIHTGEKPYKCEECGKAFNQSSTLTKH-KKIHTGEKPYVCEE 317

  Fly   155 CPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFST 219
            |.|:|.....|..|.|:|:|||||.|:.|.|.|.....|.:|...|  ...:.:.|.:|..:|..
Human   318 CGKAFKYSRILTTHKRIHTGEKPYKCNKCGKAFIASSTLSRHEFIH--MGKKHYKCEECGKAFIW 380

  Fly   220 NANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHM 284
            ::.|..|...|.....::|..|...|.....|.:| .:.|.....::||.|.|.......|:.|.
Human   381 SSVLTRHKRVHTGEKPYKCEECGKAFKYSSTLSSH-KRSHTGEKPYKCEECGKAFVASSTLSKHE 444

  Fly   285 QRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPF 349
            ..||..|.:.||.|...|.|.|....|.::||||:||:|..|.:.|..||.|..|.:.||||||:
Human   445 IIHTGKKPYKCEECGKAFNQSSSLTKHKKIHTGEKPYKCEECGKAFNQSSSLTKHKKIHTGEKPY 509

  Fly   350 RCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVDGDKP-- 412
            :|:.|..  ||:|.:.|..| ||||.::|||.||.|...|.:...|.:|     |....|:||
Human   510 KCEECGK--AFNQSSTLIKH-KKIHTREKPYKCEECGKAFHLSTHLTTH-----KILHTGEKPYR 566

  Fly   413 ---SGNQSEDAQILSVLRFNMAVVL---KKISSAQK 442
               .|.           .||.:..|   |||.|.:|
Human   567 CRECGK-----------AFNHSATLSSHKKIHSGEK 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	51/156 (33%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF93	NP_112495.2	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		COG5048	170..612	CDD:227381	122/361 (34%)
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		zf-H2C2_2	215..238	CDD:290200
		C2H2 Zn finger	231..251	CDD:275368
		zf-H2C2_2	244..268	CDD:290200	5/13 (38%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..296	CDD:290200	11/23 (48%)
		C2H2 Zn finger	287..307	CDD:275368	7/20 (35%)
		zf-H2C2_2	300..324	CDD:290200	9/24 (38%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..350	CDD:290200	12/21 (57%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		zf-H2C2_2	384..408	CDD:290200	6/23 (26%)
		C2H2 Zn finger	399..419	CDD:275368	5/20 (25%)
		zf-H2C2_2	412..435	CDD:290200	7/23 (30%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		zf-H2C2_2	440..464	CDD:290200	9/23 (39%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		zf-H2C2_2	467..492	CDD:290200	10/24 (42%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		zf-H2C2_2	495..520	CDD:290200	12/26 (46%)
		C2H2 Zn finger	511..531	CDD:275368	9/22 (41%)
		zf-H2C2_2	524..547	CDD:290200	12/23 (52%)
		C2H2 Zn finger	539..559	CDD:275368	7/24 (29%)
		zf-H2C2_2	551..576	CDD:290200	8/40 (20%)
		C2H2 Zn finger	567..587	CDD:275368	6/30 (20%)
		zf-H2C2_2	580..602	CDD:290200	6/12 (50%)
		C2H2 Zn finger	595..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000