DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF225

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001308614.1	Gene:	ZNF225 / 7768	HGNCID:	13018	Length:	706	Species:	Homo sapiens

Alignment Length:	394	Identity:	126/394 - (31%)
Similarity:	168/394 - (42%)	Gaps:	75/394 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SARKGEPVKRK-H-----HVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNH 139
            |.|.|..|.|| |     |:|.:|.|.|...:.||.|..||:.|:|.||..|.||:|...||..|
Human   242 SRRSGLYVHRKLHTGVKPHICEKCGKAFIHDSQLQEHQRIHTGEKPFKCDICCKSFRSRANLNRH 306

  Fly   140 ITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTS 204
             :..|...|.|.|..|.|||.||..|..|..:|:|||.|.|:.|.|:|.....|.:|.:.|  |.
Human   307 -SMVHMREKPFRCDTCGKSFGLKSALNSHRMVHTGEKRYKCEECGKRFIYRQDLYKHQIDH--TG 368

  Fly   205 IQQFNCTKCSASFS----------------------------TNANLRVHMERHEQGMEHRCSIC 241
            .:.:||.:|..||.                            ||:....|...|.....:||..|
Human   369 EKPYNCKECGKSFRWASGLSRHVRVHSGETTFKCEECGKGFYTNSQRYSHQRAHSGEKPYRCEEC 433

  Fly   242 ENQFANELALRAH-------------------------INQE--HHKLTQFECEICHKMIEPDED 279
            ...:...|.|..|                         :|.:  |.....|:||.|.|....:..
Human   434 GKGYKRRLDLDFHQRVHRGEKPYNCKECGKSFGWASCLLNHQRIHSGEKPFKCEECGKRFTQNSQ 498

  Fly   280 LATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHT 344
            |.||.:.|:..|...||.|...|||.||...|.|:|||.:||:|..|.:.|.....|.:|.|.||
Human   499 LYTHRRVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGVKPYKCEECGKGFNSKFNLDMHQRVHT 563

  Fly   345 GEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE--------H 401
            ||:|:.|:.|..  :||:.:.:.|| |::|..:||:.||.|...|....:|.||..        .
Human   564 GERPYNCKECGK--SFSRASSILNH-KRLHGDEKPFKCEECGKRFTENSQLHSHQRVHTGEKPYK 625

  Fly   402 CAKC 405
            |.||
Human   626 CEKC 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	62/192 (32%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	61/231 (26%)
		C2H2 Zn finger	210..230	CDD:275370	7/47 (15%)
		C2H2 Zn finger	238..260	CDD:275371	6/48 (13%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
ZNF225	NP_001308614.1	KRAB	8..48	CDD:307490
		C2H2 Zn finger	153..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		COG5048	202..634	CDD:227381	126/394 (32%)
		C2H2 Zn finger	206..226	CDD:275368
		C2H2 Zn finger	234..254	CDD:275368	6/11 (55%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		C2H2 Zn finger	290..310	CDD:275368	8/20 (40%)
		C2H2 Zn finger	318..338	CDD:275368	9/19 (47%)
		C2H2 Zn finger	346..366	CDD:275368	6/19 (32%)
		C2H2 Zn finger	374..394	CDD:275368	4/19 (21%)
		C2H2 Zn finger	402..422	CDD:275368	3/19 (16%)
		C2H2 Zn finger	430..450	CDD:275368	5/19 (26%)
		C2H2 Zn finger	458..478	CDD:275368	1/19 (5%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		C2H2 Zn finger	514..534	CDD:275368	10/19 (53%)
		C2H2 Zn finger	542..562	CDD:275368	6/19 (32%)
		C2H2 Zn finger	570..590	CDD:275368	7/22 (32%)
		C2H2 Zn finger	598..618	CDD:275368	7/19 (37%)
		C2H2 Zn finger	626..646	CDD:275368	3/4 (75%)
		C2H2 Zn finger	654..672	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910