DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF189

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_003443.2	Gene:	ZNF189 / 7743	HGNCID:	12980	Length:	626	Species:	Homo sapiens

Alignment Length:	388	Identity:	118/388 - (30%)
Similarity:	167/388 - (43%)	Gaps:	88/388 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSF 159
            |:||.:.|..:..|.:|..||:.|:||||.||||::....:|..|..| |...|.:.|::|.|||
Human   234 CNQCKQSFSQRRSLVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRT-HTGEKPYHCTKCKKSF 297

  Fly   160 ALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQH------------------------MVSH 200
            :....|..|.|:|:||:|:.|..|.|.|.....|.||                        ::.|
Human   298 SRNSLLVEHQRIHTGERPHKCGECGKAFRLSTYLIQHQKIHTGEKPFLCIECGKSFSRSSFLIEH 362

  Fly   201 HK--TSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAH--------- 254
            .:  |..:.:.|.:|..|||...||..|...|.....|:|..|...|:....|..|
Human   363 QRIHTGERPYQCKECGKSFSQLCNLTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRIHTREKT 427

  Fly   255 -----------------INQE-HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTY 301
                             |.|| :.|...::|:.|.|.......|..|.:.||..|.::|.||...
Human   428 YPYNETKESFDPNCSLVIQQEVYPKEKSYKCDECGKTFSVSAHLVQHQRIHTGEKPYLCTVCGKS 492

  Fly   302 FTQKSQYNVHMRMHTGERPYQCRIC------------HQ----------------TFAHSSVLKL 338
            |::.|....|.|:|||||||.||.|            ||                .|:.:|.|..
Human   493 FSRSSFLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVHTGNKPHKCDECGKAFSRNSGLIQ 557

  Fly   339 HIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIH---KQQKPYMCEGCHDFFKIKVELQSH 398
            |.|.||||||::|:.|:.  :|||...|.|| :|||   |.|:.:.|:.|.:.|..::.|..|
Human   558 HQRIHTGEKPYKCEKCDK--SFSQQRSLVNH-QKIHAEVKTQETHECDACGEAFNCRISLIQH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/177 (32%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	13/24 (54%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/43 (16%)
		COG5048	<192..369	CDD:227381	68/257 (26%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	8/48 (17%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	15/50 (30%)
		C2H2 Zn finger	323..343	CDD:275368	10/47 (21%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF189	NP_003443.2	KRAB	13..54	CDD:396083
		COG5048	138..524	CDD:227381	87/290 (30%)
		C2H2 Zn finger	150..170	CDD:275368
		C2H2 Zn finger	178..198	CDD:275368
		C2H2 Zn finger	206..226	CDD:275368
		C2H2 Zn finger	234..254	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..282	CDD:275368	8/20 (40%)
		C2H2 Zn finger	290..310	CDD:275368	8/19 (42%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	346..366	CDD:275368	1/19 (5%)
		C2H2 Zn finger	374..394	CDD:275368	8/19 (42%)
		C2H2 Zn finger	402..422	CDD:275368	5/19 (26%)
		C2H2 Zn finger	458..478	CDD:275368	5/19 (26%)
		C2H2 Zn finger	486..506	CDD:275368	7/19 (37%)
		C2H2 Zn finger	514..534	CDD:275368	5/19 (26%)
		zf-H2C2_2	526..551	CDD:404364	3/24 (13%)
		C2H2 Zn finger	542..562	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..579	CDD:404364	12/25 (48%)
		C2H2 Zn finger	570..590	CDD:275368	9/22 (41%)
		C2H2 Zn finger	601..621	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910