DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF177

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001166122.1	Gene:	ZNF177 / 7730	HGNCID:	12966	Length:	481	Species:	Homo sapiens

Alignment Length:	432	Identity:	126/432 - (29%)
Similarity:	185/432 - (42%)	Gaps:	77/432 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VSKEDAVSLLTDSGISLSSPPAARES--SPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKD 70
            :||.|...|.||....|....|..|:  .|..|:|::.......|   ..::..|:..||...:.
Human    63 ISKVDQEQLKTDERGILQGDCADWETQLKPKDTIAMQNIPGGKTS---NGINTAENQPGEHSLEC 124

  Fly    71 DDYVQPQLKKSAR-------KGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGK 128
            :..  .:.:|:.|       |||    |.:...:.||.|...:.|:.|:.||..|:..:..||.|
Human   125 NHC--GKFRKNTRFICTRYCKGE----KCYKYIKYSKVFNHPSTLRSHVSIHIGEKTLEFTDCRK 183

  Fly   129 SYRQAVNLKNHITTAHEHRKQFVCSQCPKSFAL------KER------------------LRLH- 168
            ::.|..:|:.|:.|....:.| ...||..||:|      :|:                  |.:|
Human   184 AFNQESSLRKHLRTPTGQKFQ-EYEQCDMSFSLHSSCSVREQIPTGEKGDECSDYGKISPLSVHT 247

  Fly   169 ---------------------------MRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQ 206
                                       :|.||||.||.|..|.|.|.....|::||.||  |..:
Human   248 KTGSVEEGLECNEHEKTFTDPLSLQNCVRTHSGEMPYECSDCGKAFIFQSSLKKHMRSH--TGEK 310

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICH 271
            .:.|..|..|||.:::|.||...|.....:.|..|...|....:|:.|: :.|.....:||..|.
Human   311 PYECDHCGKSFSQSSHLNVHKRTHTGEKPYDCKECGKAFTVPSSLQKHV-RTHTGEKPYECSDCG 374

  Fly   272 KMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVL 336
            |.......|..|.:.||..|.:.|..|...|:..|...||.|.||||:.|:|:.|.:.|.:||.|
Human   375 KAFIDQSSLKKHTRSHTGEKPYECNQCGKSFSTGSYLIVHKRTHTGEKTYECKECGKAFRNSSCL 439

  Fly   337 KLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQK 378
            ::|:|.||||||::|..||.  |||...:|..| |:||..||
Human   440 RVHVRTHTGEKPYKCIQCEK--AFSTSTNLIMH-KRIHNGQK 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/210 (26%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	8/24 (33%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	9/71 (13%)
		zf-H2C2_2	165..189	CDD:290200	13/51 (25%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	63/176 (36%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368
ZNF177	NP_001166122.1	KRAB	14..70	CDD:214630	3/6 (50%)
		C2H2 Zn finger	124..142	CDD:275368	2/19 (11%)
		C2H2 Zn finger	150..170	CDD:275368	5/19 (26%)
		C2H2 Zn finger	178..197	CDD:275368	6/18 (33%)
		COG5048	<212..442	CDD:227381	65/232 (28%)
		C2H2 Zn finger	258..278	CDD:275368	1/19 (5%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	8/19 (42%)
		C2H2 Zn finger	342..362	CDD:275368	5/20 (25%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		C2H2 Zn finger	398..418	CDD:275368	7/19 (37%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		zf-H2C2_2	439..463	CDD:404364	14/25 (56%)
		C2H2 Zn finger	454..474	CDD:275368	9/22 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910