DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF140

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011533135.1	Gene:	ZNF140 / 7699	HGNCID:	12925	Length:	458	Species:	Homo sapiens

Alignment Length:	433	Identity:	127/433 - (29%)
Similarity:	175/433 - (40%)	Gaps:	66/433 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SVSKEDAVSLLTDSGISLSSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDD 71
            |:||.|.||||              |....|.|..:..|..|.|:.::  ..|..|...::...|
Human    49 SISKPDVVSLL--------------EQGKEPWLGKREVKRDLFSVSES--SGEIKDFSPKNVIYD 97

  Fly    72 DYVQPQLKKSARKGEPV--------KRKHHV---------------------------------- 94
            |..|..:.:......||        |.|.|.
Human    98 DSSQYLIMERILSQGPVYSSFKGGWKCKDHTEMLQENQGCIRKVTVSHQEALAQHMNISTVERPY 162

  Fly    95 -CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKS 158
             |.:|.|.||.:..|..|...|:.|:|:.||:|||::.|..||..| ...|..:|...|..|.|:
Human   163 GCHECGKTFGRRFSLVLHQRTHTGEKPYACKECGKTFSQISNLVKH-QMIHTGKKPHECKDCNKT 226

  Fly   159 FALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANL 223
            |:....|..|.|.|:|||||.|..|.|.|:|...|.:|...|  ...:|:.|.||..:||:.:.|
Human   227 FSYLSFLIEHQRTHTGEKPYECTECGKAFSRASNLTRHQRIH--IGKKQYICRKCGKAFSSGSEL 289

  Fly   224 RVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHT 288
            ..|...|.....:.|..|...|.....|..| ...|...|.:||..|.|.......|..|.:.|.
Human   290 IRHQITHTGEKPYECIECGKAFRRFSHLTRH-QSIHTTKTPYECNECRKAFRCHSFLIKHQRIHA 353

  Fly   289 AVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQL 353
            ..|.:.|:.|...||..:....|.:.||||:||.|..|.:.|:.|..|.||.|.||||||:.|::
Human   354 GEKLYECDECGKVFTWHASLIQHTKSHTGEKPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKV 418

  Fly   354 CEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQ 396
            |..  :||..::|..| ::.|....||..|...::.....|.|
Human   419 CNK--SFSWSSNLAKH-QRTHTLDNPYEYENSFNYHSFLTEHQ 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/201 (29%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	57/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	3/15 (20%)
ZNF140	XP_011533135.1	KRAB	6..66	CDD:214630	9/30 (30%)
		KRAB	6..45	CDD:279668
		COG5048	160..>453	CDD:227381	101/299 (34%)
		C2H2 Zn finger	164..184	CDD:275368	7/19 (37%)
		zf-H2C2_2	176..201	CDD:290200	10/24 (42%)
		C2H2 Zn finger	192..212	CDD:275368	9/20 (45%)
		zf-H2C2_2	204..229	CDD:290200	9/25 (36%)
		C2H2 Zn finger	220..240	CDD:275368	7/19 (37%)
		zf-H2C2_2	233..257	CDD:290200	13/23 (57%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..285	CDD:290200	8/26 (31%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..313	CDD:290200	6/24 (25%)
		C2H2 Zn finger	304..324	CDD:275368	5/20 (25%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		zf-H2C2_2	372..397	CDD:290200	10/24 (42%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		zf-H2C2_2	400..424	CDD:290200	12/25 (48%)
		C2H2 Zn finger	416..436	CDD:275368	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910