DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF135

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_009065.1	Gene:	ZNF135 / 7694	HGNCID:	12919	Length:	682	Species:	Homo sapiens

Alignment Length:	403	Identity:	129/403 - (32%)
Similarity:	179/403 - (44%)	Gaps:	48/403 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KRRKSSLASLRDACVDEEE---DDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFG 103
            ||.|..|..|:..||.|:.   .:.|:..|.....::   ......||    :.:.|.:|.|.|.
Human   219 KREKPDLNVLQKTCVKEKPYKCQECGKAFSHSSALIE---HHRTHTGE----RPYECHECLKGFR 276

  Fly   104 GKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLH 168
            ..:.|.:|..||:.|:|:||..||:::.|...|..|..| |...|.:.||:|.|||:.:.....|
Human   277 NSSALTKHQRIHTGEKPYKCTQCGRTFNQIAPLIQHQRT-HTGEKPYECSECGKSFSFRSSFSQH 340

  Fly   169 MRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQG 233
            .|.|:|||||.|..|.|.|.:...|.||:..|  |..:.:.|.:|..:||.:::|..|...|...
Human   341 ERTHTGEKPYECSECGKAFRQSIHLTQHLRIH--TGEKPYQCGECGKAFSHSSSLTKHQRIHTGE 403

  Fly   234 MEHRCSICENQFANELAL----RAHINQ-------------------EHHKL----TQFECEICH 271
            ..:.|..|...|.....|    |.|..:                   ||.::    ..:.|..|.
Human   404 KPYECHECGKAFTQITPLIQHQRTHTGEKPYECGECGKAFSQSTLLTEHRRIHTGEKPYGCNECG 468

  Fly   272 KMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVL 336
            |.......|:.|.:.||..|.:.|..|...|.|.:....|.|:||||:||:|..|.:.|:|||.|
Human   469 KTFSHSSSLSQHERTHTGEKPYECSQCGKAFRQSTHLTQHQRIHTGEKPYECNDCGKAFSHSSSL 533

  Fly   337 KLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEH 401
            ..|.|.||||||:.|..|..  ||||||.|..| ::||..:|||.|..|...|.....|..|...
Human   534 TKHQRIHTGEKPYECNQCGR--AFSQLAPLIQH-QRIHTGEKPYECNQCGRAFSQSSLLIEHQRI 595

  Fly   402 CAKCPVDGDKPSG 414
            ..|     :||.|
Human   596 HTK-----EKPYG 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	64/203 (32%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	7/44 (16%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	10/22 (45%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF135	NP_009065.1	KRAB	26..85	CDD:214630
		KRAB	26..65	CDD:279668
		zf-C2H2	238..260	CDD:278523	2/24 (8%)
		C2H2 Zn finger	240..260	CDD:275368	2/22 (9%)
		COG5048	264..665	CDD:227381	117/351 (33%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		zf-H2C2_2	280..305	CDD:290200	10/24 (42%)
		C2H2 Zn finger	296..316	CDD:275368	7/20 (35%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	339..361	CDD:290200	12/21 (57%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..389	CDD:290200	8/26 (31%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		zf-H2C2_2	392..417	CDD:290200	6/24 (25%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		zf-H2C2_2	421..445	CDD:290200	3/23 (13%)
		C2H2 Zn finger	436..456	CDD:275368	2/19 (11%)
		C2H2 Zn finger	464..484	CDD:275368	5/19 (26%)
		zf-H2C2_2	476..501	CDD:290200	8/24 (33%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		zf-H2C2_2	504..529	CDD:290200	11/24 (46%)
		C2H2 Zn finger	520..540	CDD:275368	9/19 (47%)
		zf-H2C2_2	532..557	CDD:290200	13/26 (50%)
		C2H2 Zn finger	548..568	CDD:275368	10/22 (45%)
		zf-H2C2_2	561..585	CDD:290200	10/24 (42%)
		C2H2 Zn finger	576..596	CDD:275368	5/19 (26%)
		C2H2 Zn finger	604..624	CDD:275368	129/403 (32%)
		zf-H2C2_2	619..641	CDD:290200
		C2H2 Zn finger	632..652	CDD:275368
		zf-H2C2_2	644..669	CDD:290200
		C2H2 Zn finger	660..680	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910